Hormone Health Hub: Expert Insights on Testing, Balance & Better Living — methylation pathways

Single nucleotide variations (SNVs) in the enzymes that metabolise estrogen can significantly alter breast cancer risk — in some cases by as much as 12-fold when multiple variants combine. In this detailed scientific overview, Jillian Harrington PhD of ZRT Laboratory explains how variations in CYP11A1, CYP19A1 (aromatase), CYP1B1, COMT and MnSOD affect the estrogen metabolism pathway, why catechol estrogens are dangerous, and how methylation testing can reveal individual vulnerability.

Prostate cancer takes years to develop from a normal cell to a detectable tumour — which means there is a meaningful window for prevention. Three key risk factors are both testable and modifiable: BPA exposure, arsenic accumulation, and catechol oestrogen imbalance. This article explains how each one works and what men can do about it.