Hormone Health Hub: Expert Insights on Testing, Balance & Better Living — hormone optimisation

Weight management is a topic that generates a lot of questions — and hormone imbalance is one of the most common but overlooked causes. Hormone Health Educator Candace Burch of ZRT Laboratory answers the 10 most frequently asked questions about hormones and weight gain, covering everything from postmenopausal belly fat and estrogen dominance to vitamin D deficiency, thyroid imbalance and why standard blood tests often miss the picture.

Weight loss failure is rarely just about willpower or diet — hormones are almost always involved. In this Q&A, Dr. Alyssa Burns-Hill of ZRT Laboratory tackles the most common questions from people struggling to lose weight despite their best efforts: from thyroid interference by the contraceptive pill and stress-driven cortisol cravings, to estrogen-reducing supplements, natural progesterone for menopause, and why 5-HTP can be a game-changer for mood, sleep and comfort eating.

Cardiovascular disease is the leading cause of death in women, and the risk dramatically increases with menopause as estrogen levels decline. In this in-depth clinical article, Dr. Sherry LaBeck of ZRT Laboratory explains how estrogen protects the cardiovascular system through nitric oxide production, endothelial function, blood lipid regulation and anti-inflammatory mechanisms — and why the timing of estrogen replacement therapy is critical to its cardioprotective effect.

When a patient with PCOS or weight issues is told “your blood sugar is normal,” the story is far from over. In this clinical article, Dr. Alison McAllister of ZRT Laboratory explains why insulin — not glucose — is the primary driver of PCOS symptoms, weight gain, testosterone and DHEAS excess, and cortisol dysfunction. Understanding the progression from insulin resistance to hyperinsulinemia to type 2 diabetes is essential for identifying and treating PCOS at the earliest possible stage.

Hot flashes, mood instability, brain fog and memory changes during perimenopause are not “all in your head” — but they are very much in your brain. In this in-depth clinical article, Dr. Kate Placzek of ZRT Laboratory explains how declining estradiol disrupts brain glucose metabolism, neurotransmitter signalling and thermoregulation, why perimenopause represents a window of neurological vulnerability, and why the timing of hormone replacement therapy is critical to protecting long-term brain health.