{"product_id":"iodine-creatinine-test-kit-icpms","title":"ICPMS Iodine \u0026 Creatinine (I \u0026 CRTN) Test Kit","description":"\u003cp\u003e\u003cspan style=\"text-decoration: underline;\"\u003e\u003cstrong\u003eTest ID: U-326: \u003cmeta charset=\"utf-8\"\u003eICPMS The Iodine \u0026amp; Creatinine \u003c\/strong\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003eA specialised testing tool designed to measure the levels of iodine and creatinine in the human body accurately. It provides a convenient and reliable method for assessing these important substances in both males and females. The test is also suitable for children. \u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eTest Method\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cem\u003e\u003cstrong\u003eMass spectrometry (ICPMS) –\u003c\/strong\u003e utilizes different sample preparations to measure analytes, or fragments of analytes, via a mass\/charge ratio. Gold standard for high sensitivity\/specificity, extended linear range, and complex hormone analysis. Slow adoption due to cost of instrumentation and need for highly trained staff.\u003c\/em\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eIodine\u003c\/strong\u003e is an essential mineral that plays a crucial role in maintaining proper thyroid function and overall health. It is necessary for the production of thyroid hormones, which regulate metabolism, growth, and development. This kit’s Iodine spot test component allows individuals to determine their iodine levels quickly and conveniently. By assessing iodine levels, one can gain insights into thyroid health and ensure one meets daily iodine requirements.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eCreatinine is a waste product\u003c\/strong\u003e produced by the muscles during normal metabolism. It is primarily eliminated from the body through the kidneys. The Creatinine spot test in this kit allows individuals to assess the levels of creatinine in their urine. This information is valuable in evaluating kidney function, as abnormal creatinine levels may indicate potential kidney problems or conditions.\u003c\/p\u003e\n\u003cp\u003eThe I \u0026amp; CRTN Urine Spot Test Kit provides a user-friendly and non-invasive method for individuals to monitor their iodine and creatinine levels. The kit typically includes all the necessary components, such as testing strips or reagents, as well as clear instructions on how to perform the test accurately.\u003c\/p\u003e\n\u003cp\u003eBy using this test kit regularly, individuals can keep track of their iodine and creatinine levels over time, enabling them to make informed decisions about their diet, lifestyle, and overall well-being. It is important to note that while this test kit provides valuable insights, it should not be considered a substitute for professional medical advice. In case of any concerns or abnormal results, it is advisable to consult with a healthcare professional for further evaluation and guidance.\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"text-decoration: underline;\"\u003e\u003cstrong\u003eIodine Deficiency\u003c\/strong\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003eIodine deficiency or excessive iodine levels can have a negative impact on your health, including the development of goitre, hypothyroidism, acneiform eruption, and reduced mental function. This dry urine test will also help determine the effectiveness of iodine supplementation in an individual and track treatment progress. It is easy to use and only requires urine collection on a filter strip two times a day.\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"text-decoration: underline;\"\u003e\u003cstrong\u003eTest result:\u003c\/strong\u003e\u003c\/span\u003e This kit is safe, and it is easy to verify the level of iodine. Once the laboratory obtains and analyzes your sample (dried urine), you will receive the test result within 3-5 working days. In your test result, you will find the following:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\u003cem\u003eYour Iodine and Creatinine values are in graphical form, making it possible to decipher whether the iodine levels are within the normal range.\u003c\/em\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cem\u003eEasy to understand explanation regarding the functions of the tested Iodine by our laboratory professional.\u003c\/em\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cem\u003eTips and advice on what to do next.\u003c\/em\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eWe strongly recommend that you consult your results with your health care provider, GP, or doctor to know whether or not any further actions need to be carried out and get started with ample treatment if needed.\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"text-decoration: underline;\"\u003e\u003cstrong\u003eWhat is Iodine and what does it do for the human body?\u003c\/strong\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003eIodine is a mineral found in some foods. The body needs iodine to make thyroid hormones, which control the body’s metabolism and other important functions. The body also needs thyroid hormones for proper bone and brain development during pregnancy and infancy.\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"text-decoration: underline;\"\u003e\u003cstrong\u003eWho needs iodine the most and how much do I need of it?\u003c\/strong\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003eGetting enough iodine is important for everyone, but it is especially critical for infants and women who are pregnant. Each day depends on the person’s age, how much iodine is needed. Average daily recommended amounts are listed below in micrograms (mcg).\u003c\/p\u003e\n\u003ctable style=\"width: 454px;\" height=\"336\" cellpadding=\"0\" cellspacing=\"0\" border=\"0\"\u003e\n\u003cthead\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 233px;\" valign=\"top\"\u003e\n\u003cp align=\"center\"\u003e\u003cstrong\u003eLife Stage\u003c\/strong\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd style=\"width: 225px;\" valign=\"top\"\u003e\n\u003cp align=\"center\"\u003e\u003cstrong\u003eRecommended Amount\u003c\/strong\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/thead\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 233px;\" valign=\"top\"\u003e\n\u003cp\u003eBirth to 6 months\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd style=\"width: 225px;\" valign=\"top\"\u003e\n\u003cp align=\"right\"\u003e110 mcg\u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 233px;\" valign=\"top\"\u003e\n\u003cp\u003eInfants 7-12 months\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd style=\"width: 225px;\" valign=\"top\"\u003e\n\u003cp align=\"right\"\u003e130 mcg\u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 233px;\" valign=\"top\"\u003e\n\u003cp\u003eChildren 1-8 years\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd style=\"width: 225px;\" valign=\"top\"\u003e\n\u003cp align=\"right\"\u003e90 mcg\u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 233px;\" valign=\"top\"\u003e\n\u003cp\u003eChildren 9-13 years\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd style=\"width: 225px;\" valign=\"top\"\u003e\n\u003cp align=\"right\"\u003e120 mcg\u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 233px;\" valign=\"top\"\u003e\n\u003cp\u003eTeens 14-18 years\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd style=\"width: 225px;\" valign=\"top\"\u003e\n\u003cp align=\"right\"\u003e150 mcg\u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 233px;\" valign=\"top\"\u003e\n\u003cp\u003eAdults\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd style=\"width: 225px;\" valign=\"top\"\u003e\n\u003cp align=\"right\"\u003e150 mcg\u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 233px;\" valign=\"top\"\u003e\n\u003cp\u003ePregnant teens and women\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd style=\"width: 225px;\" valign=\"top\"\u003e\n\u003cp align=\"right\"\u003e220 mcg\u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 233px;\" valign=\"top\"\u003e\n\u003cp\u003eBreastfeeding teens and women\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd style=\"width: 225px;\" valign=\"top\"\u003e\n\u003cp align=\"right\"\u003e290 mcg\u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003cp\u003e\u003cspan style=\"text-decoration: underline;\"\u003e\u003cstrong\u003eIodine deficiency is a global health problem\u003c\/strong\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003eApproximately 2 billion of the world’s population is iodine deficient. According to the most recent NHANES surveys, urinary iodine levels have dropped in the U.S. by half since the 1970s, and nearly 10% of the population has some degree of iodine deficiency. Iodine deficiency is resurfacing in developed countries like the U.S. and Western Europe as efforts are made to reduce the consumption of iodine-containing salt and foods (eggs and dairy) to lower blood pressure and blood lipids.\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"text-decoration: underline;\"\u003e\u003cstrong\u003eAdequate Iodine is Essential at All Stages of Life\u003c\/strong\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003eIn the developing fetus, an adequate iodine supply from the mother is essential for thyroid hormone production, which is vital for proper neurological development. In those areas of the world with severe iodine deficiency, pregnant women are at increased risk of miscarriage, stillbirths, or giving birth to children with cretinism and severe neurological and developmental defects. Even in areas of the world with mild to moderate iodine deficiency, children born to mothers who are iodine deficient during pregnancy can have impaired intellectual development and are at increased risk for developing attention deficit and hyperactivity disorders.\u003c\/p\u003e\n\u003cp\u003eIn children and adults, iodine deficiency can lead to lower thyroid hormone synthesis and consequent symptoms and conditions of hypothyroidism. When iodine levels drop below a critical threshold, consequent low thyroid hormone levels signal the brain to increase TSH production. Excessive stimulation of the thyroid gland by TSH, caused by iodine deficiency, leads to overgrowth (goitre) in an effort to maintain steady-state thyroid hormone synthesis.\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"text-decoration: underline;\"\u003e\u003cstrong\u003eWhy high Iodine levels can be problematic:\u003c\/strong\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003eHigh iodine levels, resulting from consumption of high iodine-containing foods (e.g., seaweed) or iodine medications or supplements, can also disrupt normal thyroid function, causing goitre and both hyperthyroidism or hypothyroidism.\u003c\/p\u003e\n\u003cp\u003eHyperthyroidism is more likely to occur in the elderly who have been exposed acutely to high iodine after living for years in a low iodine environment. Chronic low iodine can lead to the development of autonomous thyroid nodules that produce excessive amounts of thyroid hormones (hyperthyroidism) when acutely exposed to high levels of iodine. Although rare, hyperthyroidism and associated thyrotoxicosis caused by excessive iodine consumption can cause arrhythmias and precipitate adverse cardiovascular events.\u003c\/p\u003e\n\u003cp\u003eIn some people, acute high iodine exposure can paradoxically suppress thyroid hormone synthesis (Wolff-Chaikoff effect) and lead to goitre and hypothyroidism. Most people with normal thyroid glands escape from the Wolff-Chaikoff effect within about two days. However, a small percentage of people, particularly those with underlying subclinical hypothyroidism or with thyroid glands compromised by autoimmune problems (e.g., Hashimoto’s), are less likely to recover from the suppressive effects of high iodine, and progress to a more severe and permanent hypothyroid state that requires thyroid medication.\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"text-decoration: underline;\"\u003e\u003cstrong\u003eHow does Iodine help prevent Infection:\u003c\/strong\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003eIodine’s effectiveness as an antimicrobial has been known for over a hundred years as it has been used for preoperative surgical skin preparation to prevent infection. As an antimicrobial, it is of relevance that iodine from the bloodstream concentrates in a broad spectrum of tissues that are repeatedly exposed to infectious organisms (e.g., skin, eyes, gastrointestinal tract, salivary gland, nasal and oral mucosa, breast ducts, uterine lining, prostate). Uptake of iodide by these tissues and enzymatic formation of reactive iodine compounds (e.g., hypoiodous acid) would serve the role of a protective antimicrobial, working in concert with the immune system.\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"text-decoration: underline;\"\u003e\u003cstrong\u003eIodine sufficiency is likely different in the Thyroid gland than in other tissues\u003c\/strong\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003eControversy exists as to how much iodine consumption is optimal. Sufficiency for the thyroid (about 150-300 µg daily consumption of iodine) is likely much lower than sufficiency for other tissues that are known to concentrate iodine such as the breast. Studies in humans have shown that for iodine to be protective (prevent benign breast disease such as fibrocystic), a minimum of 3,000 µg and optimally 6,000 µg or more of daily iodine consumption are required, far exceeding the CDC and WHO recommendations of 150-300 µg daily consumption of iodine-containing foods, salts, or supplements.\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"text-decoration: underline;\"\u003e\u003cstrong\u003eDevelopment of a patient-convenient test to measure Iodine levels in dried urine\u003c\/strong\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003eWith iodine playing so many different roles in optimising health and preventing disease in the thyroid and other tissues, it is essential that adequate iodine intake is maintained and problems associated with low or excessive iodine intake are identified and treated appropriately. To this end, ZRT has developed a simple and convenient test to measure an individual’s iodine level in urine dried on a filter strip. This method was developed to circumvent the more cumbersome collection of all urine over a 24 hour period.\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"text-decoration: underline;\"\u003e\u003cstrong\u003eCollecting and testing urinary Iodine\u003c\/strong\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003eIodine is collected twice during the day (first morning and last night void) on filter strips either by dipping the strip in urine collected in a cup, or by urinating directly on the strip. The urine-saturated filter strips are allowed to dry overnight and then sent to the laboratory for iodine and creatinine testing. The iodine content of the dried filter strips is determined following extraction and measurement by inductively coupled plasma mass spectrometry (ICP-MS). Creatinine is measured in the same urine extract by a modification of the Jaffe method. Iodine is measured in µg per litre of urine, and the average of morning and night levels is taken. The creatinine level is used to correct for hydration status of the individual because it is dependent on urine dilution. Results are therefore expressed in µg of iodine per g of creatinine.\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"text-decoration: underline;\"\u003e\u003cstrong\u003eAdvantages of dried urine for Iodine \u0026amp; Creatinine (I\u0026amp;CRTN) testing:\u003c\/strong\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e• Urine collection and shipment of the dried filter strips are simple and convenient for the patient and practitioner.\u003cbr\u003e• Dual collections of urine directly on a filter strip, upon awakening and just before bed, are far more convenient and less subject to the inherent inaccuracies of a 24 hr urine collection.\u003cbr\u003e• Iodine and creatinine in dried urine are exceptionally stable for weeks at room temperature, allowing more flexibility in the collection, shipment, testing, and storage.\u003cbr\u003e• Iodine results expressed in µg iodine per g creatinine helps to normalise results when problems exist with urine that is very concentrated or dilute.\u003cbr\u003e• Iodine testing allows for the determination of iodine status based on CDC and WHO guidelines for thyroid sufficiency, as well as extra-thyroidal sufficiency.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eHandout: \u003ca title=\"Iodine Content in Food\" href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/1885\/4859\/files\/Iodine_Content_in_Foods_PHO_557a298f-2040-4d63-a5b3-f07381814f07.pdf?v=1646916592\"\u003eIodine Content in Foods\u003c\/a\u003e\u003c\/strong\u003e\u003c\/p\u003e","brand":"ZRT","offers":[{"title":"Default Title","offer_id":32923445769,"sku":"1000","price":96.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1885\/4859\/files\/Iodine_Test_Kit.webp?v=1785073830","url":"https:\/\/hormonelab.co.uk\/products\/iodine-creatinine-test-kit-icpms","provider":"Hormone Lab UK","version":"1.0","type":"link"}