{"product_id":"male-comprehensive-hormone-profile-i","title":"Male Comprehensive Hormone Profile I | Specialist Doctor Report Included","description":"\u003cp\u003e\u003cstrong\u003eTest ID: SB-644 | Saliva 4-Point Cortisol + Blood Spot LCMS Hormones 7 with SHBG + Full Thyroid Panel\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eThe \u003cstrong\u003eMale Comprehensive Hormone Profile I\u003c\/strong\u003e is an advanced at-home health assessment for men measuring \u003cstrong\u003e18 key hormones and markers\u003c\/strong\u003e across three interconnected systems: the full daily cortisol stress rhythm by 4-point saliva testing, a complete blood spot LCMS sex hormone panel including SHBG, and a full thyroid panel including autoimmune antibodies. Using \u003cstrong\u003esaliva 4-point cortisol\u003c\/strong\u003e, \u003cstrong\u003eblood spot LCMS sex hormones\u003c\/strong\u003e, \u003cstrong\u003eSHBG\u003c\/strong\u003e, and a \u003cstrong\u003efull thyroid antibody panel\u003c\/strong\u003e, this profile delivers the androgenic and thyroid picture that standard NHS testing cannot — without the cardiometabolic panel included in higher-tier profiles.\u003c\/p\u003e\n\u003cp\u003eIn men, the cortisol daily rhythm, testosterone, SHBG, and thyroid function are mechanistically inseparable. The morning cortisol awakening response sets Leydig cell testosterone output, hepatic SHBG synthesis, and thyroid T3 activation for the entire day. Cortisol elevation at any time point depletes testosterone via pregnenolone steal and direct Leydig cell suppression, simultaneously elevates SHBG to inactivate the testosterone that remains, and impairs thyroid T4-to-T3 conversion — all at once. Hypothyroidism independently suppresses Leydig cell function and compounds every symptom of androgen decline, yet is missed by TSH alone when cortisol-driven T3 suppression is the underlying mechanism. Hashimoto’s thyroiditis progresses in men for years before TSH becomes abnormal and is directly worsened by cortisol dysregulation at night. No standard blood panel tests all three systems together. This one does.\u003c\/p\u003e\n\u003cp\u003eTest from home with confidence — no clinic visit required. Results within \u003cstrong\u003e3–5 working days\u003c\/strong\u003e.\u003c\/p\u003e\n\u003chr\u003e\n\u003ch2\u003eWhy Cortisol Rhythm, SHBG, and Thyroid Health Must Be Assessed Together in Men\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eThe 4-point cortisol rhythm is the master regulator of SHBG, free testosterone, and thyroid T3 activation in men\u003c\/strong\u003e — the morning cortisol awakening response determines Leydig cell testosterone output, hepatic SHBG synthesis rate, and thyroid T3 activation before any other system operates; elevated cortisol at any of the four time points depletes testosterone via pregnenolone steal and Leydig cell suppression, elevates SHBG to inactivate the testosterone that remains, and impairs T4-to-T3 conversion simultaneously; only four-time-point measurement reveals which phase of the day is driving the SHBG-mediated free testosterone deficiency and thyroid suppression\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSHBG is the most commonly missed cause of low testosterone symptoms in men with “normal” blood results — and is directly controlled by cortisol and thyroid status\u003c\/strong\u003e — elevated SHBG from cortisol excess, thyroid disease, oestradiol, age, or caloric restriction binds and inactivates testosterone regardless of how much the testes produce; a man with normal total testosterone but elevated SHBG has full androgenic deficiency symptoms; measuring SHBG alongside the 4-point cortisol rhythm and full thyroid panel identifies the specific mechanism driving SHBG elevation and the free testosterone consequences\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eThyroid dysfunction is a major and systematically missed cause of low free testosterone in men — and is driven by cortisol and SHBG changes measured in this panel\u003c\/strong\u003e — hypothyroidism directly suppresses Leydig cell testosterone production, elevates SHBG, and compounds every symptom of androgen decline; cortisol-driven T3 suppression produces identical effects with a normal TSH; Hashimoto’s is present for years before TSH becomes abnormal; all three patterns are invisible to TSH alone and directly measurable when assessed alongside the 4-point cortisol rhythm and SHBG\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eOestradiol excess, SHBG elevation, and HPG suppression are all cortisol-driven and thyroid-compounded in men\u003c\/strong\u003e — elevated cortisol drives visceral fat and aromatase-mediated testosterone-to-oestradiol conversion; excess oestradiol elevates SHBG and suppresses the HPG axis; hypothyroidism independently elevates SHBG and reduces Leydig cell responsiveness; the full sequence is only characterisable when all three systems are measured simultaneously\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eNight cortisol elevation worsens Hashimoto’s autoimmunity and suppresses overnight testosterone production simultaneously in men\u003c\/strong\u003e — night cortisol suppresses the deep sleep phases during which testosterone is primarily produced; drives SHBG elevation through sleep-phase hepatic cortisol-SHBG coupling; impairs sleep-phase immune regulation, worsening TPO and Tg antibody activity; and directly accelerates Hashimoto’s progression through sleep-deprivation-mediated immune dysregulation — only detectable by the 4-point cortisol assessment in this panel\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr\u003e\n\u003ch2\u003eWhat This Test Measures — 18 Markers Across Three Systems\u003c\/h2\u003e\n\u003ch3\u003eSaliva — 4-Point Cortisol Profile (4 markers)\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eMorning Cortisol (Cortisol Awakening Response):\u003c\/strong\u003e Sets Leydig cell testosterone output, hepatic SHBG synthesis rate, and thyroid T3 activation for the entire day. An exaggerated morning response drives testosterone suppression, SHBG elevation, and T3 impairment; a blunted awakening response signals HPA burnout, reduced Leydig cell responsiveness, and impaired thyroid T3 activation that persists through the entire day.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eNoon Cortisol:\u003c\/strong\u003e Elevated noon cortisol drives visceral fat deposition, aromatase-mediated testosterone-to-oestradiol conversion, SHBG rise, and impaired thyroid T4-to-T3 conversion during the peak metabolic activity window — the mechanism by which chronic midday occupational stress simultaneously suppresses free testosterone and thyroid function in men.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eEvening Cortisol:\u003c\/strong\u003e Should decline significantly to allow testosterone and growth hormone to rise during early sleep cycles. Elevated evening cortisol suppresses overnight testosterone production, elevates SHBG through hepatic cortisol-SHBG coupling, sustains thyroid T3 impairment, and independently elevates hsCRP — producing next-day fatigue, reduced recovery, and worsening androgenic and thyroid function regardless of morning values.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eNight Cortisol:\u003c\/strong\u003e Suppresses the deep sleep phases during which the majority of daily testosterone is produced; drives SHBG elevation through sleep-phase hepatic cortisol-SHBG coupling; impairs sleep-phase immune regulation controlling Hashimoto’s TPO and Tg antibody activity; and directly accelerates Hashimoto’s progression — making night cortisol the most underassessed driver of both testosterone deficiency and thyroid autoimmunity in men.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eBlood Spot LCMS — Sex Hormones \u0026amp; SHBG (8 markers)\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eOestradiol (E2):\u003c\/strong\u003e Present in men via aromatase conversion of testosterone. Physiologically important for bone density, cardiovascular protection, and cognitive function — but excess oestradiol from visceral fat, cortisol elevation, or hypothyroidism suppresses testosterone via the HPG axis, elevates SHBG, causes gynaecomastia, and raises cardiovascular risk. The oestradiol-to-free-testosterone ratio, calculated using SHBG, is the primary androgenic health indicator in men. Measured by blood spot LCMS for highest accuracy.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eOestriol (E3):\u003c\/strong\u003e Reflects oestrogen conversion pathways and aromatase activity in men. Elevated E3 indicates increased oestrogen precursor load or conversion activity; the E3-to-E2 ratio provides aromatase context beyond what E2 alone reveals.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eOestrone (E1):\u003c\/strong\u003e Produced by androgen conversion in adipose tissue. Elevated oestrone in men with visceral fat or cortisol-driven adrenal excess drives oestrogenic load, compounds HPG suppression, elevates SHBG, and worsens thyroid autoimmune inflammation.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eProgesterone (Pg):\u003c\/strong\u003e Present in men in small but clinically important amounts. Acts as a natural 5-alpha reductase inhibitor, blocking DHT conversion; has direct anti-oestrogenic, anti-inflammatory, neuroprotective, and thyroid-supportive effects; supports insulin sensitivity, sleep quality, and SHBG normalisation. Low progesterone in men is associated with elevated DHT, prostate risk, anxiety, and worsened thyroid autoimmunity.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eTestosterone (T):\u003c\/strong\u003e The primary male androgen — responsible for energy, libido, muscle mass, bone density, insulin sensitivity, HDL maintenance, and thyroid function support. Measured by blood spot LCMS for highest accuracy. Interpreted alongside SHBG to calculate free testosterone bioavailability — the clinically definitive androgenic assessment that testosterone measurement without SHBG cannot provide.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eDHEAS (DS):\u003c\/strong\u003e The primary adrenal androgen precursor in men, declining from the mid-30s and depleted under chronic cortisol elevation. Low DHEAS reduces testosterone precursor availability, impairs stress resilience, and has direct anti-inflammatory and thyroid-supportive effects. The 4-point cortisol rhythm reveals the HPA dysregulation mechanism driving DHEAS depletion.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCortisol (C) — Blood Spot LCMS:\u003c\/strong\u003e The single blood spot cortisol measurement by LCMS provides a direct comparator to the 4-point saliva cortisol rhythm, enabling cross-matrix validation and confirming the diurnal pattern with blood spot LCMS precision — the most complete cortisol assessment available in an at-home test at this tier.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSex Hormone Binding Globulin (SHBG):\u003c\/strong\u003e The bioavailability gatekeeper for testosterone in men. Elevated SHBG — driven by cortisol, thyroid disease, oestradiol excess, age, and caloric restriction — binds and inactivates testosterone regardless of its total production, causing full androgenic deficiency symptoms in men with normal total testosterone values. Essential for calculating free testosterone, interpreting the oestradiol-testosterone ratio, and identifying whether low testosterone symptoms are driven by SHBG elevation, production failure, or HPG suppression — distinctions only possible when SHBG is measured alongside the 4-point cortisol rhythm and full thyroid panel.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eBlood Spot — Full Thyroid Panel (6 markers)\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTSH:\u003c\/strong\u003e Essential first-line thyroid marker — but in men, TSH alone misses cortisol-driven T3 suppression, thyroid-SHBG interactions, and Hashimoto’s autoimmunity present for years before TSH becomes abnormal. Necessary but not sufficient for any man with unresolved fatigue, low testosterone, or elevated SHBG.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFree T3 (FT3):\u003c\/strong\u003e The active thyroid hormone that drives metabolism, energy, testosterone synthesis support, and recovery in men. Low FT3 with normal TSH is the hallmark of cortisol-driven thyroid suppression — directly identifiable by correlating each cortisol time point with the FT3 result in the integrated report.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFree T4 (FT4):\u003c\/strong\u003e The thyroid’s primary output hormone. Low FT4 with normal TSH indicates early thyroid insufficiency — often preceding symptomatic hypothyroidism, SHBG elevation, and testosterone suppression by years.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eTotal T4 (TT4):\u003c\/strong\u003e Provides full T4 context including the bound fraction — important interpretive context for men on TRT where thyroid-binding proteins and SHBG are affected simultaneously by oestradiol and cortisol changes.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eTPO Antibodies (Anti-TPO):\u003c\/strong\u003e The primary diagnostic marker for Hashimoto’s thyroiditis in men. Frequently elevated years before TSH becomes abnormal; associated with progressive Leydig cell testosterone suppression, SHBG elevation, fatigue, and poor recovery; and directly worsened by cortisol dysregulation at any time point — measurable alongside the 4-point cortisol rhythm in this panel.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eThyroglobulin Antibodies (Anti-Tg):\u003c\/strong\u003e Essential second Hashimoto’s marker. Some men have elevated Tg antibodies with normal TPO — making both necessary for complete autoimmune thyroid assessment. Night cortisol elevation worsens Tg antibody activity through sleep-deprivation immune dysregulation — detectable only by the 4-point cortisol assessment in this panel.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr\u003e\n\u003ch2\u003eWho Should Consider This Test?\u003c\/h2\u003e\n\u003cp\u003eThis test is particularly relevant for men who:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eHave persistent fatigue or exhaustion that does not improve with rest or sleep\u003c\/li\u003e\n\u003cli\u003eExperience unexplained weight gain or difficulty losing body fat, particularly around the abdomen\u003c\/li\u003e\n\u003cli\u003eHave low libido or reduced sexual interest\u003c\/li\u003e\n\u003cli\u003eExperience erectile dysfunction or reduced sexual performance\u003c\/li\u003e\n\u003cli\u003eHave poor recovery from exercise, training, or sustained high workload\u003c\/li\u003e\n\u003cli\u003eExperience brain fog, poor concentration, or reduced cognitive sharpness\u003c\/li\u003e\n\u003cli\u003eHave low mood, reduced motivation, or mild depression\u003c\/li\u003e\n\u003cli\u003eFeel cold, have temperature sensitivity, or notice a slow metabolism\u003c\/li\u003e\n\u003cli\u003eHave dry skin, hair thinning, or slow wound healing\u003c\/li\u003e\n\u003cli\u003eStruggle with insomnia, night waking, or unrefreshing sleep\u003c\/li\u003e\n\u003cli\u003eAre under chronic stress, burnout, or sustained high-pressure workload\u003c\/li\u003e\n\u003cli\u003eHave been told their testosterone is “normal” but continue to experience androgenic symptoms (elevated SHBG is frequently the explanation)\u003c\/li\u003e\n\u003cli\u003eHave diagnosed or suspected Hashimoto’s thyroiditis or autoimmune thyroid disease\u003c\/li\u003e\n\u003cli\u003eAre on TRT and want to monitor SHBG, thyroid function, and oestradiol alongside testosterone without full cardiometabolic assessment\u003c\/li\u003e\n\u003cli\u003eAre on levothyroxine and want complete thyroid monitoring alongside SHBG and sex hormone levels\u003c\/li\u003e\n\u003cli\u003eHave had thyroid or hormone testing with normal results that do not match their symptoms\u003c\/li\u003e\n\u003cli\u003eWant the complete cortisol-SHBG-testosterone-thyroid picture without a cardiometabolic panel\u003c\/li\u003e\n\u003cli\u003eAre men over 35 seeking a comprehensive androgenic, SHBG, cortisol rhythm, and thyroid health baseline\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr\u003e\n\u003ch2\u003eHow This Profile Differs From Other Hormone Lab UK Tests\u003c\/h2\u003e\n\u003cp\u003eThe \u003cstrong\u003eMale Comprehensive Hormone Profile I (SB-644M)\u003c\/strong\u003e provides the 4-point cortisol rhythm, full LCMS sex hormones + SHBG, and full thyroid panel — without the cardiometabolic panel (fasting insulin, HbA1c, HDL, triglycerides, cholesterol, hsCRP). It is the ideal choice for men who want the complete cortisol-SHBG-testosterone-thyroid assessment without cardiometabolic markers, or who are adding targeted metabolic testing separately.\u003c\/p\u003e\n\u003cp\u003eMen who want the cardiometabolic panel alongside this assessment should consider the \u003cstrong\u003eMale Comprehensive Hormone, Thyroid \u0026amp; CardioMetabolic Profile (SB-646M)\u003c\/strong\u003e, which adds six cardiometabolic markers to this complete panel.\u003c\/p\u003e\n\u003chr\u003e\n\u003ch2\u003eKey Features\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003e18-marker tri-system panel: 4-point saliva cortisol rhythm, blood spot LCMS sex hormones + SHBG, and full thyroid panel including TPO and Tg antibodies\u003c\/li\u003e\n\u003cli\u003e4-point cortisol profile — morning, noon, evening, and night — the only method revealing the full daily cortisol rhythm and its SHBG-mediated and thyroid-mediated effects on free testosterone in men\u003c\/li\u003e\n\u003cli\u003eBlood spot LCMS sex hormones — gold standard accuracy across the full androgenic range\u003c\/li\u003e\n\u003cli\u003eSHBG included — essential for calculating free testosterone and identifying the mechanism of androgenic deficiency in men with normal total testosterone\u003c\/li\u003e\n\u003cli\u003eAll three oestrogens (E1, E2, E3) for complete oestrogenic load and aromatase activity assessment\u003c\/li\u003e\n\u003cli\u003eFull 6-marker thyroid panel including TPO and Tg autoimmune antibodies for Hashimoto’s screening\u003c\/li\u003e\n\u003cli\u003eResults within \u003cstrong\u003e3–5 working days\u003c\/strong\u003e after lab receipt\u003c\/li\u003e\n\u003cli\u003eExpert analysis by a \u003cstrong\u003eHormone Specialist PhD Doctor\u003c\/strong\u003e\n\u003c\/li\u003e\n\u003cli\u003eClear graphical and numerical results with personalised commentary\u003c\/li\u003e\n\u003cli\u003eAll-inclusive price — laboratory fees included, no hidden costs\u003c\/li\u003e\n\u003cli\u003eValid for 12 months from purchase\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr\u003e\n\u003ch2\u003eHow It Works\u003c\/h2\u003e\n\u003col\u003e\n\u003cli\u003e\n\u003cstrong\u003eOrder the kit online\u003c\/strong\u003e — delivered directly to your door.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCollect your saliva samples\u003c\/strong\u003e at four time points (morning, noon, evening, night) for the cortisol rhythm panel, and your \u003cstrong\u003eblood spot sample\u003c\/strong\u003e via a simple finger-prick for the LCMS hormone, SHBG, and thyroid panels. Morning saliva should be collected before 9am for optimal cortisol awakening response accuracy.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePost your samples to the lab\u003c\/strong\u003e using the return instructions in your kit.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eReceive your results within 3–5 working days\u003c\/strong\u003e with specialist commentary and clear next-step guidance.\u003c\/li\u003e\n\u003c\/ol\u003e\n\u003chr\u003e\n\u003ch2\u003eWhat Your Report Includes\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003eAll 18 marker results with male-specific reference ranges\u003c\/li\u003e\n\u003cli\u003eVisual cortisol rhythm chart showing your full four-point daily curve\u003c\/li\u003e\n\u003cli\u003eVisual charts for all six sex hormones, SHBG, and the full thyroid panel\u003c\/li\u003e\n\u003cli\u003eIntegrated clinical interpretation of how your cortisol rhythm, testosterone, SHBG, oestradiol, and thyroid markers interact as a single male hormonal system\u003c\/li\u003e\n\u003cli\u003eSHBG-adjusted free testosterone bioavailability assessment — the definitive androgenic status calculation\u003c\/li\u003e\n\u003cli\u003eOestradiol-to-free-testosterone ratio analysis in SHBG and cortisol context\u003c\/li\u003e\n\u003cli\u003eCortisol-SHBG coupling assessment — mapping each time point to SHBG elevation and free testosterone suppression\u003c\/li\u003e\n\u003cli\u003eCortisol-thyroid T3 conversion and Leydig cell interaction assessment — mapping each cortisol time point to FT3 and functional testosterone suppression\u003c\/li\u003e\n\u003cli\u003eHashimoto’s autoimmunity assessment (TPO + Tg antibodies) in cortisol and SHBG context\u003c\/li\u003e\n\u003cli\u003eNight cortisol – Hashimoto’s progression and testosterone suppression risk assessment\u003c\/li\u003e\n\u003cli\u003eSpecialist commentary by a Hormone Specialist PhD Doctor\u003c\/li\u003e\n\u003cli\u003ePersonalised next-step recommendations\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr\u003e\n\u003ch2\u003eFrequently Asked Questions\u003c\/h2\u003e\n\u003ch3\u003eWhat does this test measure?\u003c\/h3\u003e\n\u003cp\u003e4-point saliva cortisol (morning, noon, evening, night) + Oestradiol (E2), Oestriol (E3), Oestrone (E1), Progesterone, Testosterone, DHEAS, Cortisol, SHBG (blood spot LCMS) + TSH, Free T3, Free T4, Total T4, TPO Antibodies, Thyroglobulin Antibodies (blood spot) — 18 markers in total.\u003c\/p\u003e\n\u003ch3\u003eDoes this test include cardiometabolic markers?\u003c\/h3\u003e\n\u003cp\u003eNo. This profile covers the cortisol rhythm, sex hormones, SHBG, and full thyroid panel. Men who also want fasting insulin, HbA1c, HDL, triglycerides, cholesterol, and hsCRP should consider the \u003cstrong\u003eMale Comprehensive Hormone, Thyroid \u0026amp; CardioMetabolic Profile (SB-646M)\u003c\/strong\u003e, which adds six cardiometabolic markers to this complete panel.\u003c\/p\u003e\n\u003ch3\u003eWhy is TSH alone not enough to assess thyroid health in men?\u003c\/h3\u003e\n\u003cp\u003eTSH measures the pituitary’s signal to the thyroid — not the active T3 reaching cells. Cortisol-driven T3 suppression produces functional hypothyroidism and Leydig cell testosterone suppression with a normal TSH — the most commonly missed thyroid pattern in men under chronic occupational or psychological stress. Hashimoto’s autoimmunity causes progressive thyroid damage and testosterone suppression for years before TSH becomes abnormal. SHBG elevation from thyroid disease further inactivates testosterone, compounding androgenic deficiency without changing TSH. All three patterns are invisible to TSH alone and directly assessed by this panel.\u003c\/p\u003e\n\u003ch3\u003eWhy do I need SHBG alongside my testosterone result?\u003c\/h3\u003e\n\u003cp\u003eSHBG binds and inactivates testosterone. A man with normal total testosterone but elevated SHBG — caused by cortisol, thyroid disease, oestradiol excess, age, or caloric restriction — has full androgenic deficiency symptoms despite a “normal” blood test result. SHBG is the most common reason men are told their testosterone is normal but continue to experience fatigue, low libido, and poor recovery. This panel identifies both the SHBG level and, through the 4-point cortisol rhythm and full thyroid panel, the most likely mechanism driving it.\u003c\/p\u003e\n\u003ch3\u003eCan I use this test if I am on TRT or levothyroxine?\u003c\/h3\u003e\n\u003cp\u003eYes. This test is valuable for men on TRT who want to monitor SHBG, oestradiol, and thyroid function alongside testosterone without full cardiometabolic assessment. TRT increases aromatisation, raises oestradiol, and elevates SHBG — reducing the free testosterone benefit of treatment. Levothyroxine dosing is most accurate when FT3, FT4, and antibodies are assessed alongside the SHBG and cortisol that affect T3 conversion and thyroid hormone binding.\u003c\/p\u003e\n\u003ch3\u003eIs this test suitable for men with Hashimoto’s?\u003c\/h3\u003e\n\u003cp\u003eYes. This profile includes both TPO and Tg antibodies for complete Hashimoto’s screening, alongside the 4-point cortisol rhythm that identifies which phase of the day is driving autoimmune thyroid progression — particularly night cortisol, which worsens Hashimoto’s through sleep-deprivation immune dysregulation and simultaneously suppresses overnight testosterone production.\u003c\/p\u003e\n\u003ch3\u003eWhen will I get my results?\u003c\/h3\u003e\n\u003cp\u003eWithin \u003cstrong\u003e3–5 working days\u003c\/strong\u003e after your samples reach the laboratory.\u003c\/p\u003e\n\u003ch3\u003eAre there hidden costs?\u003c\/h3\u003e\n\u003cp\u003eNo. Laboratory analysis and specialist review are fully included. You are responsible for postage to the lab.\u003c\/p\u003e\n\u003ch3\u003eHow long is the kit valid?\u003c\/h3\u003e\n\u003cp\u003e12 months from purchase.\u003c\/p\u003e\n\u003chr\u003e\n\u003ch2\u003eWhy We Partner with ZRT Laboratory\u003c\/h2\u003e\n\u003cp\u003eAt Hormone Lab UK, every home test kit is analysed by \u003cstrong\u003eZRT Laboratory\u003c\/strong\u003e, a globally recognised, \u003cstrong\u003eCLIA-certified\u003c\/strong\u003e diagnostic and research laboratory specialising in hormone testing, thyroid testing, fertility testing, adrenal function, neurotransmitter analysis, cardiometabolic health, heavy metals, and wellness testing. Founded in 1998 by renowned biochemist and breast cancer researcher \u003cstrong\u003eDr. David Zava, PhD\u003c\/strong\u003e, ZRT has become one of the world’s leading laboratories for advanced functional health testing.\u003c\/p\u003e\n\u003cp\u003eWith \u003cstrong\u003emore than 11 million laboratory tests\u003c\/strong\u003e performed and healthcare professionals in \u003cstrong\u003eover 96 countries\u003c\/strong\u003e relying on its expertise, ZRT is recognised for scientific excellence, analytical accuracy, and continuous innovation. The laboratory pioneered \u003cstrong\u003eat-home saliva hormone testing\u003c\/strong\u003e, introduced the \u003cstrong\u003efirst commercially available dried blood spot (DBS) hormone tests\u003c\/strong\u003e, and developed \u003cstrong\u003eDried Urine Testing (DUTS)\u003c\/strong\u003e, helping make advanced laboratory diagnostics more accessible and clinically meaningful.\u003c\/p\u003e\n\u003cp\u003eEvery sample is analysed using state-of-the-art \u003cstrong\u003eLC-MS\/MS\u003c\/strong\u003e and \u003cstrong\u003eICP-MS\u003c\/strong\u003e technology under rigorous quality control standards. ZRT collaborates with the \u003cstrong\u003eCDC\u003c\/strong\u003e, \u003cstrong\u003eNIH\u003c\/strong\u003e, and leading universities, supporting ongoing research and advances in laboratory medicine.\u003c\/p\u003e","brand":"ZRT Laboratory","offers":[{"title":"Default Title","offer_id":57961680306557,"sku":"1021","price":399.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1885\/4859\/files\/SalivaandBloodSpotHormoneTestKit.webp?v=1785073903","url":"https:\/\/hormonelab.co.uk\/pl\/products\/male-comprehensive-hormone-profile-i","provider":"Hormone Lab UK","version":"1.0","type":"link"}