{"product_id":"female-advanced-hormone-stress-thyroid-test","title":"Female Advanced Hormone, Stress \u0026 Thyroid Test | Specialist Doctor Report Included","description":"\u003cp\u003e\u003cstrong\u003eTest ID: SB-650 | Saliva LCMS Hormones 7 with 4-Point Cortisol + Blood Spot Full Thyroid Panel\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eThe \u003cstrong\u003eFemale Advanced Hormone, Stress \u0026amp; Thyroid Test\u003c\/strong\u003e is the most clinically comprehensive at-home hormone profile available for women, measuring \u003cstrong\u003e16 key hormones and markers\u003c\/strong\u003e across three interconnected systems: sex hormone balance, the full daily cortisol stress rhythm, and complete thyroid function including autoimmune markers. It combines \u003cstrong\u003esaliva LCMS (Liquid Chromatography–Mass Spectrometry)\u003c\/strong\u003e testing for sex hormones and cortisol with a \u003cstrong\u003efull blood spot thyroid panel\u003c\/strong\u003e — the gold standard analytical combination for assessing the female hormonal network in its entirety.\u003c\/p\u003e\n\u003cp\u003eThis test is designed for women who want more than a partial answer. In women, oestrogen, progesterone, testosterone, DHEAS, cortisol, and thyroid hormones do not function independently — they form a tightly integrated regulatory network in which disruption to any one system cascades across the others. Cortisol suppresses progesterone and impairs thyroid T3 conversion. Thyroid insufficiency drives oestrogen dominance. Low DHEAS depletes the adrenal androgen reserve that supports sex hormone production under stress. This test measures all three systems together, revealing the full hormonal picture that single-system tests and standard GP blood panels systematically miss.\u003c\/p\u003e\n\u003cp\u003eTest from home with confidence — no clinic visit required. Results within \u003cstrong\u003e3–5 working days\u003c\/strong\u003e.\u003c\/p\u003e\n\u003chr\u003e\n\u003ch2\u003eWhy This Is the Most Important Hormone Test a Woman Can Take\u003c\/h2\u003e\n\u003cp\u003eNo other at-home test combines LCMS sex hormone accuracy with 4-point cortisol rhythm assessment and a full autoimmune thyroid panel in a single kit. Here is why each component is essential and why they must be assessed together:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eCortisol is the master regulator of female hormonal balance\u003c\/strong\u003e — chronic stress suppresses progesterone through pregnenolone steal, drives oestrogen dominance, depletes DHEAS, impairs T4-to-T3 thyroid conversion, and disrupts the hypothalamic-pituitary axis that governs the entire female reproductive cycle; without the 4-point cortisol profile, the root cause of most female hormonal symptoms remains undetected\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eThyroid dysfunction is the most commonly missed driver of female hormonal symptoms\u003c\/strong\u003e — hypothyroidism, cortisol-driven T3 suppression, and Hashimoto’s autoimmunity produce symptoms identical to sex hormone imbalance — fatigue, weight gain, hair loss, brain fog, low mood, cycle irregularities — and are frequently misattributed to oestrogen deficiency or perimenopause; TSH alone misses the majority of clinically relevant thyroid dysfunction in women\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eLCMS is the gold standard for bioavailable sex hormone measurement in women\u003c\/strong\u003e — standard immunoassay blood tests measure total hormones including the bound, inactive fraction; saliva LCMS measures only the free, bioavailable fraction that actually reaches cells and drives symptoms; this distinction is critical in women, where protein-binding and oestrogen-related SHBG fluctuations mean total and free hormone levels can diverge significantly\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAll three oestrogens must be measured together\u003c\/strong\u003e — oestradiol (E2) alone does not reveal oestrogen metabolism, conversion pathways, or postmenopausal oestrogen dominance driven by oestrone (E1); oestriol (E3) reflects metabolic oestrogen activity; together they reveal dominance patterns, conversion imbalances, and oestrogen metabolic risk that single-oestrogen tests miss\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eProgesterone-to-oestrogen ratio determines whether oestrogen dominance is present\u003c\/strong\u003e — this ratio — the most clinically important value in female hormonal health — can only be calculated when both markers are measured simultaneously; low progesterone relative to oestrogen drives PMS, heavy periods, breast tenderness, anxiety, insomnia, and perimenopausal symptoms that are misattributed to oestrogen deficiency\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr\u003e\n\u003ch2\u003eWhat This Test Measures\u003c\/h2\u003e\n\u003ch3\u003eSaliva LCMS — Sex Hormones\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eOestradiol (E2):\u003c\/strong\u003e The primary and most potent oestrogen in premenopausal women — driving reproductive health, bone density, cardiovascular protection, collagen production, and mood stability. Declining E2 in perimenopause triggers hot flushes, night sweats, vaginal dryness, low mood, and accelerated bone loss. Measured by LCMS for bioavailable (free) fraction accuracy.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eOestriol (E3):\u003c\/strong\u003e Reflects oestrogen conversion pathways and metabolic activity. E3 is a product of oestrogen metabolism; its ratio relative to E2 and E1 reveals how oestrogen is being processed and whether conversion pathways are functioning optimally.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eOestrone (E1):\u003c\/strong\u003e The dominant postmenopausal oestrogen, produced by conversion of androgens in adipose tissue. Elevated E1 in women with higher body fat, or those on HRT, can drive oestrogen-dominant symptoms — breast tenderness, bloating, and increased proliferative risk — when not appropriately balanced by progesterone.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eProgesterone (Pg):\u003c\/strong\u003e The essential counterbalance to oestrogen in women. Progesterone supports sleep quality, mood stability, bone health, uterine lining integrity, and thyroid function; it is a natural anti-anxiety hormone, cortisol inhibitor, and anti-inflammatory agent. Low progesterone — from anovulation, chronic stress, luteal phase deficiency, or perimenopause — is one of the most common and most undertreated causes of female hormonal symptoms.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eTestosterone (T):\u003c\/strong\u003e Essential in women for libido, energy, muscle tone, motivation, and cognitive clarity. Both low testosterone (persistent fatigue, low libido, poor exercise response, depression) and high testosterone (PCOS, acne, cycle irregularities, facial hair) are clinically significant and accurately measured by LCMS saliva testing.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eDHEAS (DS):\u003c\/strong\u003e The primary adrenal androgen precursor in women, declining steadily from the mid-30s and depleted rapidly under chronic stress. Low DHEAS is associated with persistent fatigue, reduced libido, poor stress resilience, worsening perimenopausal symptoms, and reduced testosterone precursor availability. Elevated DHEAS — from adrenal overactivity or PCOS — drives androgen excess symptoms.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eSaliva — 4-Point Cortisol Profile\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eMorning Cortisol:\u003c\/strong\u003e The Cortisol Awakening Response — the morning surge that activates metabolism, sets progesterone balance, and establishes hormonal tone for the entire day. A blunted morning response signals HPA axis burnout; an exaggerated response indicates high stress reactivity and progesterone suppression, worsening oestrogen dominance from the first hours of the day.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eNoon Cortisol:\u003c\/strong\u003e Elevated noon cortisol suppresses progesterone, impairs thyroid T3 conversion, drives blood sugar instability, and promotes afternoon energy crashes and sugar cravings in women. Effects are amplified in the luteal phase and during perimenopause when progesterone reserves are already declining.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eEvening Cortisol:\u003c\/strong\u003e Should be declining significantly to allow progesterone and melatonin to rise, supporting hormonal restoration and sleep onset. Elevated evening cortisol in women disrupts the hormonal shift essential for sleep quality, thyroid cellular uptake, and overnight reproductive hormone recovery.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eNight Cortisol:\u003c\/strong\u003e Elevated night cortisol is a primary driver of insomnia, night sweats, and overnight blood sugar dysregulation in women — particularly during perimenopause and menopause, when progesterone is no longer available to buffer cortisol during sleep and support overnight hormonal restoration.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eBlood Spot — Full Thyroid Panel\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTSH (Thyroid Stimulating Hormone):\u003c\/strong\u003e The standard first-line thyroid screen — but in women, TSH alone misses cortisol-driven T3 suppression, oestrogen-related changes in thyroid hormone binding, early thyroid insufficiency, and Hashimoto’s autoimmunity that may be present for years before TSH becomes abnormal. Essential context, not a complete picture.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFree T3 (FT3):\u003c\/strong\u003e The active thyroid hormone that drives metabolism, energy, mood, temperature regulation, and cognitive function in women. Low FT3 with normal TSH is the hallmark of cortisol-driven thyroid suppression — the most commonly missed pattern in women with ongoing fatigue, weight gain, and brain fog despite “normal” thyroid blood tests.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFree T4 (FT4):\u003c\/strong\u003e The thyroid’s primary output hormone. Low FT4 with normal TSH indicates early thyroid insufficiency or impaired conversion — particularly relevant for women on HRT or the contraceptive pill, which increase thyroid-binding globulin and reduce free T4 availability.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eTotal T4 (TT4):\u003c\/strong\u003e Measures total circulating T4 including the bound fraction. Provides critical context for interpreting FT4 in women whose oestrogen levels alter thyroid hormone binding — a distinction that matters clinically when free and total T4 diverge.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eTPO Antibodies (Anti-TPO):\u003c\/strong\u003e The primary diagnostic marker for Hashimoto’s thyroiditis — the autoimmune condition responsible for the majority of hypothyroidism in women. Elevated TPO antibodies are frequently present years before TSH becomes abnormal, making early detection possible only through direct antibody testing.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eThyroglobulin Antibodies (Anti-Tg):\u003c\/strong\u003e A second autoimmune marker essential for complete Hashimoto’s screening. Some women have elevated Tg antibodies with normal TPO — making both markers necessary for accurate autoimmune thyroid assessment and early detection of progressive thyroid decline.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr\u003e\n\u003ch2\u003eWho Should Consider This Test?\u003c\/h2\u003e\n\u003cp\u003eThis test is the ideal choice for women who experience:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003ePersistent fatigue or exhaustion that does not improve with rest or sleep\u003c\/li\u003e\n\u003cli\u003eUnexplained weight gain or difficulty losing weight despite diet and exercise\u003c\/li\u003e\n\u003cli\u003ePMS, heavy, irregular, painful, or absent periods\u003c\/li\u003e\n\u003cli\u003eBreast tenderness, bloating, or mood changes in the second half of the cycle\u003c\/li\u003e\n\u003cli\u003ePerimenopausal or menopausal symptoms: hot flushes, night sweats, vaginal dryness, low mood\u003c\/li\u003e\n\u003cli\u003eLow libido or reduced sexual interest\u003c\/li\u003e\n\u003cli\u003eBrain fog, poor concentration, or memory issues\u003c\/li\u003e\n\u003cli\u003eAnxiety, irritability, or emotional volatility\u003c\/li\u003e\n\u003cli\u003eInsomnia, night waking, or unrefreshing sleep\u003c\/li\u003e\n\u003cli\u003eHair thinning, dry skin, brittle nails, or feeling cold\u003c\/li\u003e\n\u003cli\u003eAcne, excess facial hair, or scalp hair loss\u003c\/li\u003e\n\u003cli\u003eFertility difficulties or recurrent miscarriage\u003c\/li\u003e\n\u003cli\u003eDiagnosed or suspected PCOS, Hashimoto’s thyroiditis, or oestrogen dominance\u003c\/li\u003e\n\u003cli\u003eCurrently on HRT, the contraceptive pill, or thyroid medication and wanting a full hormonal picture\u003c\/li\u003e\n\u003cli\u003ePrevious partial hormone or thyroid testing with inconclusive results\u003c\/li\u003e\n\u003cli\u003eChronic stress, burnout, or sustained emotional exhaustion\u003c\/li\u003e\n\u003cli\u003eWomen seeking the most comprehensive single at-home hormonal health assessment available\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr\u003e\n\u003ch2\u003eKey Features\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003e16-marker advanced triple-system panel: saliva LCMS sex hormones, 4-point cortisol, and full blood spot thyroid profile\u003c\/li\u003e\n\u003cli\u003eSaliva LCMS — the gold standard for bioavailable sex hormone measurement in women\u003c\/li\u003e\n\u003cli\u003eAll three oestrogens (E1, E2, E3) for complete oestrogen metabolism and dominance assessment\u003c\/li\u003e\n\u003cli\u003eFull thyroid panel including TPO and Tg autoimmune antibodies\u003c\/li\u003e\n\u003cli\u003e4-point cortisol profile revealing the complete daily adrenal stress rhythm\u003c\/li\u003e\n\u003cli\u003eResults within \u003cstrong\u003e3–5 working days\u003c\/strong\u003e after lab receipt\u003c\/li\u003e\n\u003cli\u003eExpert analysis by a \u003cstrong\u003eHormone Specialist PhD Doctor\u003c\/strong\u003e\n\u003c\/li\u003e\n\u003cli\u003eClear graphical and numerical results with personalised commentary\u003c\/li\u003e\n\u003cli\u003eAll-inclusive price — laboratory fees included, no hidden costs\u003c\/li\u003e\n\u003cli\u003eValid for 12 months from purchase\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr\u003e\n\u003ch2\u003eHow It Works\u003c\/h2\u003e\n\u003col\u003e\n\u003cli\u003e\n\u003cstrong\u003eOrder the kit online\u003c\/strong\u003e — delivered directly to your door.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCollect your saliva samples\u003c\/strong\u003e at four time points (morning, noon, evening, night) for the sex hormone and cortisol panel, and your \u003cstrong\u003eblood spot sample\u003c\/strong\u003e via a simple finger-prick for the thyroid panel, following the detailed instructions provided. Guidance on optimal cycle timing is included.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePost your samples to the lab\u003c\/strong\u003e using the return instructions included in your kit.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eReceive your results within 3–5 working days\u003c\/strong\u003e, with specialist commentary and clear next-step guidance.\u003c\/li\u003e\n\u003c\/ol\u003e\n\u003chr\u003e\n\u003ch2\u003eWhat Your Report Includes\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003eAll 16 marker results with female-specific reference ranges\u003c\/li\u003e\n\u003cli\u003eVisual charts for all six sex hormones, your full 4-point cortisol daily curve, and thyroid panel values\u003c\/li\u003e\n\u003cli\u003eClinical interpretation of how your oestrogens, progesterone, testosterone, DHEAS, cortisol, and thyroid markers interact as an integrated system\u003c\/li\u003e\n\u003cli\u003eOestrogen-progesterone ratio and dominance pattern analysis\u003c\/li\u003e\n\u003cli\u003eCortisol-thyroid interaction assessment — including whether cortisol is impairing your T3 conversion\u003c\/li\u003e\n\u003cli\u003eSpecialist commentary by a Hormone Specialist PhD Doctor\u003c\/li\u003e\n\u003cli\u003ePersonalised next-step recommendations\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr\u003e\n\u003ch2\u003eFrequently Asked Questions\u003c\/h2\u003e\n\u003ch3\u003eWhat does this test measure?\u003c\/h3\u003e\n\u003cp\u003eOestradiol (E2), Oestriol (E3), Oestrone (E1), Progesterone, Testosterone, DHEAS (saliva LCMS) plus 4-point Cortisol (saliva: morning, noon, evening, night) plus TSH, Free T3, Free T4, Total T4, TPO Antibodies, and Thyroglobulin Antibodies (blood spot) — 16 markers in total.\u003c\/p\u003e\n\u003ch3\u003eWhy is LCMS used for sex hormones in this test?\u003c\/h3\u003e\n\u003cp\u003eLCMS (Liquid Chromatography–Mass Spectrometry) is the most analytically precise method available for sex hormone measurement. It measures the free, bioavailable fraction of hormones in saliva — the portion actually reaching your cells and driving symptoms. Standard immunoassay blood tests measure total hormone including the bound, inactive fraction, which frequently masks the imbalances most relevant to symptoms in women.\u003c\/p\u003e\n\u003ch3\u003eWhen in my cycle should I collect my samples?\u003c\/h3\u003e\n\u003cp\u003eGuidance on optimal cycle timing is included in the kit. For most women, collection in the luteal phase (days 19–21 of a 28-day cycle) provides the most clinically meaningful progesterone and oestrogen values.\u003c\/p\u003e\n\u003ch3\u003eCan I use this test if I am on HRT, the contraceptive pill, or thyroid medication?\u003c\/h3\u003e\n\u003cp\u003eYes. HRT and the pill significantly affect oestrogen, progesterone, and thyroid hormone binding — which is precisely why a comprehensive panel including LCMS bioavailable hormone measurement and full thyroid markers is more informative than standard blood tests for women on hormonal treatment. Follow the timing guidance in your kit.\u003c\/p\u003e\n\u003ch3\u003eHow accurate is the LCMS hormone testing?\u003c\/h3\u003e\n\u003cp\u003eLC-MS\/MS (Liquid Chromatography–Tandem Mass Spectrometry) is the reference standard method for hormone analysis, used by national reference laboratories and research institutions. It provides superior specificity and sensitivity compared to immunoassay methods, particularly for low-concentration hormones such as oestradiol and progesterone in non-pregnant women.\u003c\/p\u003e\n\u003ch3\u003eWhen will I get my results?\u003c\/h3\u003e\n\u003cp\u003eWithin \u003cstrong\u003e3–5 working days\u003c\/strong\u003e after your samples reach the laboratory.\u003c\/p\u003e\n\u003ch3\u003eAre there hidden costs?\u003c\/h3\u003e\n\u003cp\u003eNo. Laboratory analysis and specialist review are fully included. You are responsible for postage to the lab.\u003c\/p\u003e\n\u003ch3\u003eHow long is the kit valid?\u003c\/h3\u003e\n\u003cp\u003e12 months from purchase.\u003c\/p\u003e\n\u003chr\u003e\n\u003ch2\u003eWhy We Partner with ZRT Laboratory\u003c\/h2\u003e\n\u003cp\u003eAt Hormone Lab UK, every home test kit is analysed by \u003cstrong\u003eZRT Laboratory\u003c\/strong\u003e, a globally recognised, \u003cstrong\u003eCLIA-certified\u003c\/strong\u003e diagnostic and research laboratory specialising in hormone testing, thyroid testing, fertility testing, adrenal function, neurotransmitter analysis, cardiometabolic health, heavy metals, and wellness testing. Founded in 1998 by renowned biochemist and breast cancer researcher \u003cstrong\u003eDr. David Zava, PhD\u003c\/strong\u003e, ZRT has become one of the world’s leading laboratories for advanced functional health testing.\u003c\/p\u003e\n\u003cp\u003eWith \u003cstrong\u003emore than 11 million laboratory tests\u003c\/strong\u003e performed and healthcare professionals in \u003cstrong\u003eover 96 countries\u003c\/strong\u003e relying on its expertise, ZRT is recognised for scientific excellence, analytical accuracy, and continuous innovation. The laboratory pioneered \u003cstrong\u003eat-home saliva hormone testing\u003c\/strong\u003e, introduced the \u003cstrong\u003efirst commercially available dried blood spot (DBS) hormone tests\u003c\/strong\u003e, and developed \u003cstrong\u003eDried Urine Testing (DUTS)\u003c\/strong\u003e, helping make advanced laboratory diagnostics more accessible and clinically meaningful.\u003c\/p\u003e\n\u003cp\u003eEvery sample is analysed using state-of-the-art \u003cstrong\u003eLC-MS\/MS\u003c\/strong\u003e and \u003cstrong\u003eICP-MS\u003c\/strong\u003e technology under rigorous quality control standards. ZRT collaborates with the \u003cstrong\u003eCDC\u003c\/strong\u003e, \u003cstrong\u003eNIH\u003c\/strong\u003e, and leading universities, supporting ongoing research and advances in laboratory medicine.\u003c\/p\u003e","brand":"Hormone Lab UK","offers":[{"title":"Default Title","offer_id":58618327499133,"sku":"1022-F","price":369.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1885\/4859\/files\/SalivaandBloodSpotHormoneTestKit.webp?v=1785073903","url":"https:\/\/hormonelab.co.uk\/pl\/products\/female-advanced-hormone-stress-thyroid-test","provider":"Hormone Lab UK","version":"1.0","type":"link"}