{"product_id":"male-comprehensive-hormone-thyroid-cardiometabolic-profile","title":"Male Comprehensive Hormone, Thyroid \u0026 CardioMetabolic Profile | Specialist Doctor Report Included","description":"\u003cp\u003e\u003cstrong\u003eTest ID: SB-646M | Saliva 4-Point Cortisol + Blood Spot LCMS Hormones 7 with SHBG + Full Thyroid \u0026amp; CardioMetabolic Panel\u003c\/strong\u003e\u003c\/p\u003e\n\n\u003cp\u003eThe \u003cstrong\u003eMale Comprehensive Hormone, Thyroid \u0026amp; CardioMetabolic Profile\u003c\/strong\u003e is the most complete at-home health assessment available for men anywhere in the UK, measuring \u003cstrong\u003e24 key hormones and markers\u003c\/strong\u003e across four interconnected systems in a single kit: the full daily cortisol stress rhythm, a complete blood spot LCMS sex hormone panel including SHBG, the full thyroid panel including autoimmune antibodies, and a six-marker cardiometabolic panel. It is the only at-home test to combine a \u003cstrong\u003e4-point saliva cortisol assessment\u003c\/strong\u003e with \u003cstrong\u003eblood spot LCMS sex hormones\u003c\/strong\u003e, \u003cstrong\u003eSHBG\u003c\/strong\u003e, a \u003cstrong\u003efull thyroid antibody panel\u003c\/strong\u003e, and \u003cstrong\u003efasting insulin\u003c\/strong\u003e — providing the complete androgenic-thyroid-metabolic picture that standard NHS testing cannot.\u003c\/p\u003e\n\n\u003cp\u003eIn men, testosterone, cortisol, thyroid hormones, SHBG, and insulin form a single integrated regulatory network where disruption to any system cascades through all the others simultaneously. The morning cortisol awakening response sets Leydig cell testosterone output, thyroid T3 activation, and insulin sensitivity for the entire day. Chronic cortisol elevation depletes testosterone via pregnenolone steal and direct Leydig cell suppression, elevates SHBG to inactivate the testosterone that remains, impairs thyroid T4-to-T3 conversion, and drives insulin resistance — all in parallel. Hypothyroidism independently suppresses Leydig cell function and compounds every symptom of androgen decline — but is missed by TSH alone when cortisol-driven T3 suppression is the mechanism. And SHBG — elevated by cortisol, thyroid disease, and oestradiol — determines how much testosterone is actually available to drive androgenic function. No standard blood panel tests all four systems together. This one does.\u003c\/p\u003e\n\n\u003cp\u003eTest from home with confidence — no clinic visit required. Results within \u003cstrong\u003e3–5 working days\u003c\/strong\u003e.\u003c\/p\u003e\n\n\u003chr\u003e\n\n\u003ch2\u003eThe Male Hormonal System: Why All Four Must Be Tested Together\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eThe 4-point cortisol rhythm is the master regulator of testosterone, thyroid, and metabolic function in men\u003c\/strong\u003e — the cortisol awakening response sets daily Leydig cell testosterone output, thyroid T3 activation, and insulin sensitivity before any other system operates; elevated cortisol at any time point suppresses testosterone via pregnenolone steal and direct Leydig cell inhibition, elevates SHBG to inactivate remaining testosterone, impairs thyroid T4-to-T3 conversion, drives insulin resistance, raises triglycerides, suppresses HDL, and elevates hsCRP; only four-time-point measurement maps the full daily rhythm — a single cortisol value cannot identify morning-normal\/evening-elevated patterns, blunted awakening response with midday excess, or night cortisol elevation that suppresses overnight testosterone production and worsens Hashimoto’s autoimmunity\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSHBG is the bioavailability gatekeeper for testosterone in men\u003c\/strong\u003e — SHBG binds and inactivates testosterone regardless of its total production; elevated SHBG — driven by cortisol elevation, thyroid disease, oestradiol excess, age, and caloric restriction — means a man can have normal total testosterone but critically low free testosterone, producing full androgenic deficiency symptoms with a normal blood test result; SHBG measurement is essential for interpreting every testosterone result in men, and its combination with the 4-point cortisol and thyroid panel identifies the specific mechanisms driving SHBG elevation\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eThyroid dysfunction is a major and systematically missed cause of low free testosterone in men\u003c\/strong\u003e — hypothyroidism directly suppresses Leydig cell testosterone production, elevates SHBG (further reducing free testosterone), impairs the protein metabolism and energy generation that testosterone depends on, and compounds every symptom of androgen decline; cortisol-driven T3 suppression produces identical effects with a normal TSH; Hashimoto’s is present for years before TSH becomes abnormal; and TSH alone misses all three patterns — making the full thyroid panel including FT3, FT4, TT4, TPO, and Tg antibodies, assessed alongside SHBG and cortisol, essential for any man with unresolved androgenic symptoms\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eInsulin resistance and testosterone decline are mutually reinforcing, SHBG-mediated, and thyroid-compounded in men\u003c\/strong\u003e — elevated insulin drives visceral fat and aromatase-driven testosterone-to-oestradiol conversion; elevated oestradiol elevates SHBG and suppresses the HPG axis; hypothyroidism compounds insulin resistance through thermogenic and hepatic glucose metabolism impairment; fasting insulin is the earliest detectable marker of this process — elevated years before HbA1c becomes abnormal and directly linked to every downstream androgenic and cardiometabolic deterioration in men\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ehsCRP is the convergence biomarker of all four systems in men\u003c\/strong\u003e — elevated simultaneously by low free testosterone (worsened by elevated SHBG), cortisol dysregulation at any time point, insulin resistance, visceral fat, oestradiol excess, and Hashimoto’s autoimmunity; a stronger independent predictor of cardiovascular events and all-cause mortality in men than LDL cholesterol; and a direct measure of the integrated inflammatory load that only a four-system assessment with SHBG can fully attribute and target\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003chr\u003e\n\n\u003ch2\u003eWhat This Test Measures — 24 Markers Across Four Systems\u003c\/h2\u003e\n\n\u003ch3\u003eSaliva — 4-Point Cortisol Profile (4 markers)\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eMorning Cortisol (Cortisol Awakening Response):\u003c\/strong\u003e Sets Leydig cell testosterone output, thyroid T3 activation, SHBG hepatic synthesis rate, and insulin sensitivity for the entire day. An exaggerated morning response drives testosterone suppression, SHBG elevation, and morning insulin resistance; a blunted awakening response signals HPA burnout, impaired thyroid activation, and reduced Leydig cell responsiveness that persists through the day.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eNoon Cortisol:\u003c\/strong\u003e Elevated noon cortisol drives visceral fat deposition, impairs thyroid T4-to-T3 conversion, promotes aromatase-driven testosterone-to-oestradiol conversion, elevates SHBG, raises triglycerides via hepatic lipid dysregulation, and suppresses HDL — the direct mechanism by which chronic midday occupational stress accelerates androgenic decline and cardiometabolic deterioration in men.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eEvening Cortisol:\u003c\/strong\u003e Should decline significantly to allow testosterone and growth hormone to rise during early sleep cycles. Elevated evening cortisol suppresses overnight testosterone production, elevates SHBG through hepatic cortisol-SHBG coupling, maintains insulin resistance into the night, and impairs thyroid cellular uptake — producing next-day fatigue, reduced recovery, and worsening androgenic and metabolic function regardless of the morning value.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eNight Cortisol:\u003c\/strong\u003e Suppresses the deep sleep phases during which the majority of daily testosterone is produced and growth hormone mediates fat metabolism. Drives overnight visceral fat accumulation, fasting insulin elevation, hsCRP rise, aromatase excess, and SHBG elevation — and directly worsens Hashimoto’s autoimmune activity through sleep-deprivation-mediated immune dysregulation.\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003ch3\u003eBlood Spot LCMS — Sex Hormones \u0026amp; SHBG (8 markers)\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eOestradiol (E2):\u003c\/strong\u003e Present in men via aromatase conversion of testosterone. Essential for bone density, cardiovascular protection, and cognitive function — but excess oestradiol from visceral fat, cortisol elevation, or hypothyroidism suppresses testosterone via the HPG axis, elevates SHBG, causes gynaecomastia, raises triglycerides, and elevates cardiovascular risk. The oestradiol-to-free-testosterone ratio — calculated using SHBG — is the primary androgenic and cardiometabolic health indicator in men. Measured by blood spot LCMS for the highest available accuracy.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eOestriol (E3):\u003c\/strong\u003e Reflects oestrogen conversion pathways and aromatase activity in men. Elevated E3 indicates increased oestrogen precursor load or conversion; the E3-to-E2 ratio provides metabolic oestrogen context and aromatase activity assessment beyond what E2 alone reveals.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eOestrone (E1):\u003c\/strong\u003e Produced by androgen conversion in adipose tissue. Elevated oestrone in men with visceral fat drives systemic oestrogenic load, compounds testosterone and HPG suppression, elevates SHBG, and is associated with increased cardiometabolic and inflammatory risk. A key indicator of adipose-driven hormonal disruption in men.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eProgesterone (Pg):\u003c\/strong\u003e Present in men in small but clinically important amounts. Acts as a natural 5-alpha reductase inhibitor, blocking DHT conversion; has direct anti-oestrogenic, anti-inflammatory, neuroprotective, and cardioprotective effects; supports insulin sensitivity, sleep quality, and thyroid function. Low progesterone in men is associated with elevated DHT, prostate risk, anxiety, and increased cardiometabolic inflammation.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eTestosterone (T):\u003c\/strong\u003e The primary male androgen — responsible for energy, libido, muscle mass, bone density, insulin sensitivity, HDL maintenance, and cardiovascular health. Measured by blood spot LCMS for the highest accuracy across the clinical range. Interpreted alongside SHBG to calculate free testosterone bioavailability — the clinically definitive androgenic assessment that standard blood tests without SHBG cannot provide.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eDHEAS (DS):\u003c\/strong\u003e The primary adrenal androgen precursor in men, declining from the mid-30s and depleted under chronic cortisol elevation. Low DHEAS reduces testosterone precursor availability, impairs stress resilience, and has direct anti-inflammatory and insulin-sensitising effects. The 4-point cortisol rhythm directly reveals the HPA dysregulation mechanism driving DHEAS depletion.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCortisol (C) — Blood Spot LCMS:\u003c\/strong\u003e The single blood spot cortisol measurement by LCMS provides a direct comparator to the 4-point saliva cortisol rhythm, enabling cross-matrix cortisol validation and the most clinically complete cortisol assessment available in an at-home test. Confirms the diurnal pattern identified by the saliva rhythm with the precision of blood spot LCMS measurement.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSex Hormone Binding Globulin (SHBG):\u003c\/strong\u003e The bioavailability gatekeeper for testosterone in men. Elevated SHBG — driven by cortisol elevation, thyroid disease, oestradiol excess, age, and caloric restriction — binds and inactivates testosterone regardless of its total production, causing full androgenic deficiency symptoms in men with normal total testosterone values. SHBG is essential for calculating free testosterone, interpreting the oestradiol-testosterone ratio, and identifying whether low testosterone symptoms are driven by SHBG elevation, production failure, or HPG suppression — mechanisms only distinguishable when SHBG is measured alongside cortisol and thyroid markers.\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003ch3\u003eBlood Spot — Full Thyroid Panel (6 markers)\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTSH:\u003c\/strong\u003e Essential first-line thyroid marker — but in men, TSH alone misses cortisol-driven T3 suppression, thyroid-SHBG interactions, and Hashimoto’s autoimmunity present years before TSH becomes abnormal. Necessary but not sufficient for any man with unresolved fatigue, low testosterone, or elevated SHBG.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFree T3 (FT3):\u003c\/strong\u003e The active thyroid hormone that drives metabolism, testosterone synthesis support, energy, and recovery in men. Low FT3 with normal TSH is the hallmark of cortisol-driven thyroid suppression — directly identifiable by correlating the 4-point cortisol rhythm with the FT3 result in a single integrated report.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFree T4 (FT4):\u003c\/strong\u003e The thyroid’s primary output hormone. Low FT4 with normal TSH indicates early thyroid insufficiency — often preceding symptomatic hypothyroidism, testosterone suppression, and SHBG elevation by years.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eTotal T4 (TT4):\u003c\/strong\u003e Provides full T4 context including the bound fraction — important interpretive context for men on TRT where thyroid-binding proteins and SHBG may be affected simultaneously.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eTPO Antibodies (Anti-TPO):\u003c\/strong\u003e The primary diagnostic marker for Hashimoto’s thyroiditis in men. Frequently elevated years before TSH becomes abnormal; associated with progressive Leydig cell testosterone suppression, SHBG elevation, fatigue, and metabolic deterioration; and directly worsened by insulin resistance and cortisol dysregulation — both measured by this panel across four time points and six cardiometabolic markers.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eThyroglobulin Antibodies (Anti-Tg):\u003c\/strong\u003e Essential second Hashimoto’s marker. Some men have elevated Tg antibodies with normal TPO — making both necessary for complete autoimmune thyroid assessment. Night cortisol elevation worsens Tg antibody activity through sleep-deprivation-mediated immune dysregulation — directly measurable by the 4-point cortisol rhythm in this panel.\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003ch3\u003eBlood Spot — CardioMetabolic Panel (6 markers)\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eFasting Insulin:\u003c\/strong\u003e The earliest detectable marker of insulin resistance in men — elevated years before HbA1c becomes abnormal. Directly promoted by cortisol at any time point, low free testosterone (worsened by elevated SHBG), visceral fat, and hypothyroidism. Elevated fasting insulin drives aromatase activity, increases oestradiol conversion and SHBG elevation, independently raises cardiovascular risk, and is closely linked to erectile dysfunction and androgenic decline. Also directly worsens Hashimoto’s thyroid antibody activity through systemic inflammation.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eHbA1c:\u003c\/strong\u003e Reflects average blood sugar over 8–12 weeks. Men with chronically elevated cortisol, low free testosterone, elevated SHBG, and hypothyroidism have markedly elevated risk of pre-diabetes and type 2 diabetes; HbA1c provides the medium-term blood sugar context that anchors the fasting insulin, cortisol, and thyroid interaction assessment.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eHDL Cholesterol:\u003c\/strong\u003e The protective cardiovascular fraction directly maintained by free testosterone and suppressed by SHBG-mediated testosterone deficiency, insulin resistance, cortisol elevation, and hypothyroidism — four pathways all assessed comprehensively by this panel.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eTriglycerides:\u003c\/strong\u003e Elevated by cortisol at any of the four time points, insulin resistance, oestradiol excess, and hypothyroidism simultaneously. Rise before LDL changes and are a primary cardiometabolic risk marker for men with visceral fat, hormonal decline, elevated SHBG, and thyroid dysfunction.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eTotal Cholesterol:\u003c\/strong\u003e Directly elevated by hypothyroidism and low free testosterone. Rising cholesterol in men with fatigue, low libido, and elevated SHBG is frequently a combined hormonal, thyroid, and cortisol event rather than a dietary one — requiring the integrated assessment this panel provides.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ehsCRP (High-Sensitivity C-Reactive Protein):\u003c\/strong\u003e One of the strongest independent predictors of cardiovascular events and all-cause mortality in men. Elevated simultaneously by low free testosterone, SHBG-mediated androgenic deficiency, cortisol dysregulation at any time point, insulin resistance, visceral fat, oestradiol excess, and Hashimoto’s autoimmunity — all pathways directly and comprehensively assessed by this panel. The convergence biomarker of the male hormonal-thyroid-metabolic system.\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003chr\u003e\n\n\u003ch2\u003eWho Should Consider This Test?\u003c\/h2\u003e\n\u003cp\u003eThis is the most appropriate test for men who:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eHave persistent fatigue, low energy, or exhaustion that does not improve with rest\u003c\/li\u003e\n\u003cli\u003eExperience unexplained weight gain or difficulty losing body fat, particularly around the abdomen\u003c\/li\u003e\n\u003cli\u003eHave low libido or reduced sexual interest\u003c\/li\u003e\n\u003cli\u003eExperience erectile dysfunction or reduced sexual performance\u003c\/li\u003e\n\u003cli\u003eHave poor recovery from exercise, training, or sustained high workload\u003c\/li\u003e\n\u003cli\u003eExperience brain fog, poor concentration, or reduced cognitive sharpness\u003c\/li\u003e\n\u003cli\u003eHave low mood, reduced motivation, or mild depression\u003c\/li\u003e\n\u003cli\u003eFeel cold, have temperature sensitivity, or notice a slow metabolism\u003c\/li\u003e\n\u003cli\u003eHave dry skin, hair thinning, or slow wound healing\u003c\/li\u003e\n\u003cli\u003eExperience sugar cravings, energy crashes, or afternoon slumps\u003c\/li\u003e\n\u003cli\u003eHave elevated cholesterol, triglycerides, or blood sugar on previous testing\u003c\/li\u003e\n\u003cli\u003eStruggle with insomnia, night waking, or unrefreshing sleep\u003c\/li\u003e\n\u003cli\u003eAre under chronic stress, burnout, or sustained high-pressure workload\u003c\/li\u003e\n\u003cli\u003eHave symptoms of low testosterone with normal or inconclusive standard blood test results\u003c\/li\u003e\n\u003cli\u003eHave been told their testosterone is “normal” but continue to have androgenic symptoms (high SHBG is frequently the explanation)\u003c\/li\u003e\n\u003cli\u003eAre currently on TRT and want to monitor SHBG, thyroid, oestradiol, and cardiometabolic markers alongside testosterone\u003c\/li\u003e\n\u003cli\u003eHave diagnosed or suspected Hashimoto’s thyroiditis or autoimmune thyroid disease\u003c\/li\u003e\n\u003cli\u003eAre on levothyroxine and want complete thyroid monitoring alongside SHBG and sex hormone levels\u003c\/li\u003e\n\u003cli\u003eHave had previous thyroid or hormone testing with results that do not match their symptoms\u003c\/li\u003e\n\u003cli\u003eHave a family history of thyroid disease, heart disease, diabetes, or metabolic syndrome\u003c\/li\u003e\n\u003cli\u003eAre men over 35 seeking the single most comprehensive at-home androgenic, thyroid, and cardiometabolic health assessment available\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003chr\u003e\n\n\u003ch2\u003eKey Features\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003e24-marker quad-system panel: 4-point saliva cortisol rhythm, blood spot LCMS sex hormones + SHBG, full thyroid panel, and full cardiometabolic panel — the most comprehensive at-home male health assessment available in the UK\u003c\/li\u003e\n\u003cli\u003e4-point cortisol profile — morning, noon, evening, and night — the only measurement method that reveals the full daily cortisol rhythm and its effects on testosterone, SHBG, thyroid, and metabolic function\u003c\/li\u003e\n\u003cli\u003eBlood spot LCMS sex hormones — gold standard accuracy across the full androgenic range\u003c\/li\u003e\n\u003cli\u003eSHBG included — essential for calculating free testosterone, interpreting oestradiol-testosterone ratio, and identifying the mechanism of androgenic deficiency in men with normal total testosterone\u003c\/li\u003e\n\u003cli\u003eAll three oestrogens (E1, E2, E3) for complete oestrogenic load and aromatase activity assessment\u003c\/li\u003e\n\u003cli\u003eFull 6-marker thyroid panel including TPO and Tg autoimmune antibodies for Hashimoto’s screening\u003c\/li\u003e\n\u003cli\u003eSix cardiometabolic markers — fasting insulin, HbA1c, HDL, triglycerides, total cholesterol, hsCRP\u003c\/li\u003e\n\u003cli\u003eResults within \u003cstrong\u003e3–5 working days\u003c\/strong\u003e after lab receipt\u003c\/li\u003e\n\u003cli\u003eExpert analysis by a \u003cstrong\u003eHormone Specialist PhD Doctor\u003c\/strong\u003e\n\u003c\/li\u003e\n\u003cli\u003eClear graphical and numerical results with personalised commentary\u003c\/li\u003e\n\u003cli\u003eAll-inclusive price — laboratory fees included, no hidden costs\u003c\/li\u003e\n\u003cli\u003eValid for 12 months from purchase\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003chr\u003e\n\n\u003ch2\u003eHow It Works\u003c\/h2\u003e\n\u003col\u003e\n\u003cli\u003e\n\u003cstrong\u003eOrder the kit online\u003c\/strong\u003e — delivered directly to your door.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCollect your saliva samples\u003c\/strong\u003e at four time points (morning, noon, evening, night) for the cortisol rhythm panel, and your \u003cstrong\u003eblood spot sample\u003c\/strong\u003e via a simple finger-prick for the LCMS hormone, SHBG, thyroid, and cardiometabolic panels, following the detailed instructions. Morning saliva should be collected before 9am for optimal cortisol awakening response accuracy.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePost your samples to the lab\u003c\/strong\u003e using the return instructions in your kit.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eReceive your results within 3–5 working days\u003c\/strong\u003e with specialist commentary and clear next-step guidance.\u003c\/li\u003e\n\u003c\/ol\u003e\n\n\u003chr\u003e\n\n\u003ch2\u003eWhat Your Report Includes\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003eAll 24 marker results with male-specific reference ranges\u003c\/li\u003e\n\u003cli\u003eVisual cortisol rhythm chart showing your full four-point daily curve\u003c\/li\u003e\n\u003cli\u003eVisual charts for all six sex hormones, SHBG, the full thyroid panel, and all six cardiometabolic markers\u003c\/li\u003e\n\u003cli\u003eIntegrated clinical interpretation of how your cortisol rhythm, testosterone, SHBG, oestradiol, thyroid markers, and cardiometabolic results interact as a single male hormonal-metabolic system\u003c\/li\u003e\n\u003cli\u003eSHBG-adjusted free testosterone bioavailability assessment — the definitive androgenic status calculation\u003c\/li\u003e\n\u003cli\u003eOestradiol-to-free-testosterone ratio analysis in SHBG and cortisol context\u003c\/li\u003e\n\u003cli\u003eCortisol-thyroid T3 conversion and Leydig cell interaction assessment — directly mapping each cortisol time point to FT3, SHBG, and functional testosterone suppression\u003c\/li\u003e\n\u003cli\u003eHashimoto’s autoimmunity assessment (TPO + Tg antibodies) in cortisol, insulin, and SHBG context\u003c\/li\u003e\n\u003cli\u003eInsulin resistance pattern assessment (fasting insulin + HbA1c)\u003c\/li\u003e\n\u003cli\u003eCardiovascular risk profile in full androgenic, SHBG, and thyroid hormonal context (HDL, triglycerides, cholesterol, hsCRP)\u003c\/li\u003e\n\u003cli\u003eSpecialist commentary by a Hormone Specialist PhD Doctor\u003c\/li\u003e\n\u003cli\u003ePersonalised next-step recommendations\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003chr\u003e\n\n\u003ch2\u003eFrequently Asked Questions\u003c\/h2\u003e\n\n\u003ch3\u003eWhat does this test measure?\u003c\/h3\u003e\n\u003cp\u003e4-point saliva cortisol (morning, noon, evening, night) + Oestradiol (E2), Oestriol (E3), Oestrone (E1), Progesterone, Testosterone, DHEAS, Cortisol, SHBG (blood spot LCMS) + TSH, Free T3, Free T4, Total T4, TPO Antibodies, Thyroglobulin Antibodies (blood spot) + Fasting Insulin, HbA1c, HDL Cholesterol, Triglycerides, Total Cholesterol, hsCRP (blood spot) — 24 markers in total.\u003c\/p\u003e\n\n\u003ch3\u003eHow does this test differ from the Male Advanced Hormone, Thyroid \u0026amp; CardioMetabolic Test?\u003c\/h3\u003e\n\u003cp\u003eThe Male Comprehensive Profile (SB-646M) adds three significant capabilities over the SB-649M: the full \u003cstrong\u003e4-point cortisol daily rhythm\u003c\/strong\u003e (morning, noon, evening, night) replacing a single cortisol value — essential for identifying which part of the day is suppressing testosterone, elevating SHBG, impairing thyroid T3 conversion, or driving cardiometabolic deterioration; \u003cstrong\u003eSHBG measurement\u003c\/strong\u003e — the bioavailability gatekeeper that determines how much testosterone is actually free and active; and a \u003cstrong\u003eblood spot LCMS cortisol comparator\u003c\/strong\u003e for cross-matrix validation. It is the most comprehensive at-home male health assessment available.\u003c\/p\u003e\n\n\u003ch3\u003eWhy do I need SHBG tested alongside my testosterone?\u003c\/h3\u003e\n\u003cp\u003eSHBG binds and inactivates testosterone in the bloodstream. A man with normal total testosterone but elevated SHBG — driven by cortisol, thyroid disease, oestradiol excess, age, or caloric restriction — has the full symptoms of androgen deficiency despite a “normal” blood test result. SHBG is the most common reason men are told their testosterone is normal but continue to experience fatigue, low libido, and poor recovery. Without SHBG, testosterone results cannot be accurately interpreted.\u003c\/p\u003e\n\n\u003ch3\u003eWhy is a 4-point cortisol rhythm more informative than a single cortisol measurement?\u003c\/h3\u003e\n\u003cp\u003eA single cortisol measurement cannot identify the pattern of cortisol dysregulation — whether the morning awakening response is blunted, whether cortisol peaks at midday or evening, or whether night cortisol is suppressing overnight testosterone production. A blunted morning + elevated evening pattern produces completely different effects on SHBG, thyroid T3, and insulin than an elevated morning + normal-decline pattern — yet both may show a similar single value. The four-point rhythm identifies exactly which phase of the day is driving the androgenic, thyroid, and metabolic components of your symptoms.\u003c\/p\u003e\n\n\u003ch3\u003eCan I use this test if I am on TRT or levothyroxine?\u003c\/h3\u003e\n\u003cp\u003eYes — and this is the most appropriate test for men on TRT. TRT increases aromatisation, elevates oestradiol, raises SHBG, alters thyroid binding, and affects HDL and triglycerides — all directly assessed here. SHBG measurement alongside the 4-point cortisol rhythm identifies whether TRT dose adjustment, cortisol management, or thyroid optimisation is the most productive next step. Levothyroxine dosing is most accurate when FT3, FT4, and antibodies are assessed alongside SHBG and the cortisol that impairs T3 conversion.\u003c\/p\u003e\n\n\u003ch3\u003eIs this test suitable for men with Hashimoto’s or suspected thyroid disease?\u003c\/h3\u003e\n\u003cp\u003eYes — this is the most comprehensive thyroid and androgenic assessment available in an at-home test for men. TPO and Tg antibodies are assessed alongside the 4-point cortisol rhythm and insulin markers that directly drive Hashimoto’s progression, the SHBG that reflects thyroid-driven testosterone inactivation, and the full cardiometabolic panel that quantifies the metabolic consequences of thyroid dysfunction.\u003c\/p\u003e\n\n\u003ch3\u003eWhen will I get my results?\u003c\/h3\u003e\n\u003cp\u003eWithin \u003cstrong\u003e3–5 working days\u003c\/strong\u003e after your samples reach the laboratory.\u003c\/p\u003e\n\n\u003ch3\u003eAre there hidden costs?\u003c\/h3\u003e\n\u003cp\u003eNo. Laboratory analysis and specialist review are fully included. You are responsible for postage to the lab.\u003c\/p\u003e\n\n\u003ch3\u003eHow long is the kit valid?\u003c\/h3\u003e\n\u003cp\u003e12 months from purchase.\u003c\/p\u003e\n\n\u003chr\u003e\n\n\u003ch2\u003eWhy We Partner with ZRT Laboratory\u003c\/h2\u003e\n\u003cp\u003eAt Hormone Lab UK, every home test kit is analysed by \u003cstrong\u003eZRT Laboratory\u003c\/strong\u003e, a globally recognised, \u003cstrong\u003eCLIA-certified\u003c\/strong\u003e diagnostic and research laboratory specialising in hormone testing, thyroid testing, fertility testing, adrenal function, neurotransmitter analysis, cardiometabolic health, heavy metals, and wellness testing. Founded in 1998 by renowned biochemist and breast cancer researcher \u003cstrong\u003eDr. David Zava, PhD\u003c\/strong\u003e, ZRT has become one of the world’s leading laboratories for advanced functional health testing.\u003c\/p\u003e\n\u003cp\u003eWith \u003cstrong\u003emore than 11 million laboratory tests\u003c\/strong\u003e performed and healthcare professionals in \u003cstrong\u003eover 96 countries\u003c\/strong\u003e relying on its expertise, ZRT is recognised for scientific excellence, analytical accuracy, and continuous innovation. The laboratory pioneered \u003cstrong\u003eat-home saliva hormone testing\u003c\/strong\u003e, introduced the \u003cstrong\u003efirst commercially available dried blood spot (DBS) hormone tests\u003c\/strong\u003e, and developed \u003cstrong\u003eDried Urine Testing (DUTS)\u003c\/strong\u003e, helping make advanced laboratory diagnostics more accessible and clinically meaningful.\u003c\/p\u003e\n\u003cp\u003eEvery sample is analysed using state-of-the-art \u003cstrong\u003eLC-MS\/MS\u003c\/strong\u003e and \u003cstrong\u003eICP-MS\u003c\/strong\u003e technology under rigorous quality control standards. ZRT collaborates with the \u003cstrong\u003eCDC\u003c\/strong\u003e, \u003cstrong\u003eNIH\u003c\/strong\u003e, and leading universities, supporting ongoing research and advances in laboratory medicine.\u003c\/p\u003e","brand":"Hormone Lab UK","offers":[{"title":"Default Title","offer_id":57961452274045,"sku":null,"price":570.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1885\/4859\/files\/SalivaandBloodSpotHormoneTestKit.webp?v=1785073903","url":"https:\/\/hormonelab.co.uk\/fr\/products\/male-comprehensive-hormone-thyroid-cardiometabolic-profile","provider":"Hormone Lab UK","version":"1.0","type":"link"}