{"product_id":"female-hormone-cardiometabolic-test","title":"Female Hormone \u0026 CardioMetabolic Test | Specialist Doctor Report Included","description":"\u003cp\u003e\u003cstrong\u003eTest ID: SB-651 | Saliva LCMS Hormones 7 with 4-Point Cortisol + Blood Spot CardioMetabolic Panel\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eThe \u003cstrong\u003eFemale Hormone \u0026amp; CardioMetabolic Test\u003c\/strong\u003e is the most comprehensive at-home combined hormone and metabolic health profile available for women, measuring \u003cstrong\u003e16 key hormones and markers\u003c\/strong\u003e across three interconnected systems: sex hormone balance, the full daily cortisol rhythm, and cardiometabolic health. It combines \u003cstrong\u003esaliva LCMS (Liquid Chromatography–Mass Spectrometry)\u003c\/strong\u003e sex hormone and cortisol testing with a \u003cstrong\u003eblood spot cardiometabolic panel\u003c\/strong\u003e — providing the complete picture of how female hormones, stress physiology, and metabolic function interact to determine energy, body composition, cardiovascular risk, and long-term health.\u003c\/p\u003e\n\u003cp\u003eWhat makes this test uniquely valuable for women is the clinical connection it reveals. Cortisol, oestrogen, progesterone, and insulin do not operate in isolation — they form a tightly coupled metabolic-hormonal network in which disruption to one system cascades directly through the others. Cortisol drives insulin resistance and visceral fat. Insulin resistance increases aromatase activity and oestrogen dominance. Oestrogen decline after menopause raises LDL, reduces HDL, increases triglycerides, and elevates hsCRP. And progesterone deficiency — worsened by cortisol — allows all of these processes to accelerate. This test measures the full network in a single kit, revealing root causes that single-system tests consistently miss.\u003c\/p\u003e\n\u003cp\u003eTest from home with confidence — no clinic visit required. Results within \u003cstrong\u003e3–5 working days\u003c\/strong\u003e.\u003c\/p\u003e\n\u003chr\u003e\n\u003ch2\u003eWhy Female Hormones and Cardiometabolic Health Must Be Assessed Together\u003c\/h2\u003e\n\u003cp\u003eIn women, sex hormones and metabolic markers are not separate health concerns — they are mechanistically linked:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eOestrogen is the primary cardiovascular protector in women — and its decline is the primary cardiovascular risk driver\u003c\/strong\u003e — oestradiol supports HDL cholesterol, suppresses LDL oxidation, maintains vascular elasticity, and inhibits systemic inflammation via hsCRP; as oestradiol declines in perimenopause and menopause, HDL falls, LDL rises, triglycerides increase, and hsCRP elevates in a predictable pattern that raises cardiovascular disease risk to match or exceed that of men — yet women are far less likely to be monitored or treated\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCortisol is the primary driver of insulin resistance and visceral fat in women\u003c\/strong\u003e — chronic cortisol elevation impairs insulin receptor sensitivity, drives glucose into storage as abdominal fat, raises triglycerides, suppresses HDL, and elevates hsCRP; simultaneously, cortisol suppresses progesterone — creating oestrogen dominance — and depletes DHEAS, accelerating the hormonal ageing process that worsens metabolic risk\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eInsulin resistance is hormonally amplified in women at every life stage\u003c\/strong\u003e — PCOS is defined by insulin resistance even in lean women; the luteal phase naturally reduces insulin sensitivity under progesterone influence; perimenopause removes oestrogen’s insulin-sensitising effect; and postmenopause creates a sustained insulin-resistant state that raises HbA1c, fasting insulin, triglycerides, and cardiovascular risk simultaneously\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ehsCRP connects the hormonal and metabolic systems in women\u003c\/strong\u003e — elevated C-reactive protein in women reflects the convergence of cortisol dysregulation, insulin resistance, visceral fat, oestrogen decline, and DHEAS depletion; it is a stronger independent predictor of cardiovascular disease in women than LDL cholesterol, and is directly modifiable through hormonal and metabolic intervention\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eDHEAS and progesterone are the anti-inflammatory, anti-metabolic-ageing hormones in women\u003c\/strong\u003e — both decline under chronic stress; low DHEAS reduces the androgen and oestrogen precursor pool available to peripheral tissues; low progesterone allows oestrogen dominance to drive inflammation and fat storage; together their depletion accelerates insulin resistance, cardiovascular risk, and the hormonal deterioration of perimenopause\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr\u003e\n\u003ch2\u003eWhat This Test Measures\u003c\/h2\u003e\n\u003ch3\u003eSaliva LCMS — Sex Hormones\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eOestradiol (E2):\u003c\/strong\u003e The primary and most potent oestrogen in premenopausal women — driving reproductive health, bone density, cardiovascular protection, insulin sensitivity, and mood stability. Declining E2 in perimenopause triggers hot flushes, night sweats, low mood, and the cardiometabolic risk shift that characterises the postmenopausal years. Measured by LCMS for bioavailable (free) fraction accuracy.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eOestriol (E3):\u003c\/strong\u003e Reflects oestrogen conversion pathways and metabolic activity. E3 is a product of oestrogen and progesterone metabolism; its ratio relative to E2 and E1 provides insight into how oestrogen is being processed and whether protective conversion pathways are functioning optimally.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eOestrone (E1):\u003c\/strong\u003e The dominant postmenopausal oestrogen, produced by conversion of androgens in adipose tissue. Elevated E1 in women with higher body fat or on HRT can drive oestrogen-dominant symptoms and proliferative risk; declining E1 in lean postmenopausal women reflects the total oestrogenic deficit that drives cardiometabolic vulnerability.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eProgesterone (Pg):\u003c\/strong\u003e The essential counterbalance to oestrogen and a key anti-inflammatory, cardioprotective hormone in women. Progesterone supports insulin sensitivity, reduces vascular inflammation, inhibits cortisol-driven fat storage, and promotes restorative sleep. Low progesterone — from anovulation, chronic stress, luteal phase deficiency, or perimenopause — worsens oestrogen dominance, raises hsCRP, and accelerates cardiometabolic risk.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eTestosterone (T):\u003c\/strong\u003e Essential in women for energy, libido, muscle mass, and metabolic rate. Low testosterone is associated with fatigue, low libido, poor exercise response, and reduced lean mass; elevated testosterone (as in PCOS) drives insulin resistance, visceral fat, and cardiometabolic risk directly. LCMS measures the bioavailable fraction for clinical accuracy.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eDHEAS (DS):\u003c\/strong\u003e The primary adrenal androgen precursor in women, declining from the mid-30s and depleted under chronic stress. Low DHEAS is associated with fatigue, reduced testosterone precursor availability, poor stress resilience, and accelerated metabolic ageing. DHEAS has direct anti-inflammatory and insulin-sensitising effects — making its decline a significant contributor to the metabolic deterioration of perimenopause and beyond.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eSaliva — 4-Point Cortisol Profile\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eMorning Cortisol:\u003c\/strong\u003e The Cortisol Awakening Response — sets blood sugar, insulin sensitivity, and hormonal tone for the day. A blunted morning response signals HPA burnout and impaired metabolic activation; an exaggerated response drives morning blood sugar dysregulation, progesterone suppression, and insulin resistance from the first hours of the day.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eNoon Cortisol:\u003c\/strong\u003e Elevated noon cortisol in women drives blood sugar instability, afternoon energy crashes, sugar cravings, and visceral fat deposition. Simultaneously impairs T4-to-T3 thyroid conversion, suppresses progesterone, and raises triglycerides — effects amplified in the luteal phase and during perimenopause.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eEvening Cortisol:\u003c\/strong\u003e Should be declining to allow progesterone, melatonin, and growth hormone to rise — supporting overnight metabolic restoration, anti-inflammatory repair, and hormonal recovery. Elevated evening cortisol in women prevents this shift, maintaining the catabolic, insulin-resistant state into the night.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eNight Cortisol:\u003c\/strong\u003e Elevated night cortisol drives overnight blood sugar dysregulation, suppresses the deep sleep during which growth hormone mediates overnight fat metabolism, and prevents the anti-inflammatory resolution that should occur during sleep — directly elevating fasting insulin and hsCRP in women.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eBlood Spot — CardioMetabolic Panel\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eFasting Insulin:\u003c\/strong\u003e The earliest detectable marker of insulin resistance in women — elevated years before HbA1c or fasting glucose becomes abnormal. In women, fasting insulin is directly driven by cortisol excess, low progesterone, oestrogen decline, and PCOS. Elevated fasting insulin promotes visceral fat, raises triglycerides, suppresses HDL, and is the primary driver of the PCOS hormonal cycle in women.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eHbA1c (Glycated Haemoglobin):\u003c\/strong\u003e Reflects average blood sugar regulation over the preceding 8–12 weeks. Women’s risk of pre-diabetes and type 2 diabetes rises markedly in perimenopause and postmenopause as oestrogen’s insulin-sensitising effects are lost; HbA1c provides the medium-term blood sugar picture that contextualises the fasting insulin result.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eHDL Cholesterol:\u003c\/strong\u003e The protective cardiovascular fraction directly supported by oestradiol. HDL falls significantly after menopause as oestrogen declines, removing a key cardiovascular protection. Low HDL is also a primary metabolic syndrome marker in women — directly worsened by insulin resistance, visceral fat, and cortisol elevation.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eTriglycerides:\u003c\/strong\u003e Strongly associated with cortisol elevation, insulin resistance, and oestrogen decline in women. Triglycerides often rise before LDL changes and are a primary cardiometabolic risk marker — particularly relevant for perimenopausal, postmenopausal, and PCOS women.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eTotal Cholesterol:\u003c\/strong\u003e Provides overall lipid context. Rising total cholesterol in perimenopausal and postmenopausal women is a direct, predictable consequence of declining oestradiol and requires integrated hormonal and metabolic assessment.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ehsCRP (High-Sensitivity C-Reactive Protein):\u003c\/strong\u003e The gold standard systemic inflammation marker and a stronger independent predictor of cardiovascular disease in women than LDL cholesterol. Elevated hsCRP in women reflects the convergence of cortisol dysregulation, insulin resistance, visceral fat, oestrogen decline, and progesterone deficiency — and is a key target for combined hormonal and lifestyle intervention.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr\u003e\n\u003ch2\u003eWho Should Consider This Test?\u003c\/h2\u003e\n\u003cp\u003eThis test is particularly relevant for women who experience:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003ePersistent fatigue or exhaustion that does not improve with sleep or rest\u003c\/li\u003e\n\u003cli\u003eUnexplained weight gain or difficulty losing weight, particularly around the abdomen\u003c\/li\u003e\n\u003cli\u003eSugar cravings, energy crashes, or afternoon slumps\u003c\/li\u003e\n\u003cli\u003eElevated cholesterol or triglycerides on previous testing\u003c\/li\u003e\n\u003cli\u003eBlood sugar irregularities, a history of gestational diabetes, or pre-diabetes\u003c\/li\u003e\n\u003cli\u003ePMS, heavy, irregular, or absent periods\u003c\/li\u003e\n\u003cli\u003eBreast tenderness, bloating, or mood swings in the second half of the cycle\u003c\/li\u003e\n\u003cli\u003ePerimenopausal or menopausal symptoms: hot flushes, night sweats, vaginal dryness, low mood\u003c\/li\u003e\n\u003cli\u003eLow libido or reduced sexual interest\u003c\/li\u003e\n\u003cli\u003eBrain fog, poor concentration, or memory issues\u003c\/li\u003e\n\u003cli\u003eAnxiety, irritability, or emotional volatility\u003c\/li\u003e\n\u003cli\u003eInsomnia, night waking, or unrefreshing sleep\u003c\/li\u003e\n\u003cli\u003eChronic stress or burnout\u003c\/li\u003e\n\u003cli\u003eDiagnosed or suspected PCOS or oestrogen dominance\u003c\/li\u003e\n\u003cli\u003eCurrently on HRT and wanting to monitor metabolic and inflammatory markers\u003c\/li\u003e\n\u003cli\u003eFamily history of diabetes, heart disease, or metabolic syndrome\u003c\/li\u003e\n\u003cli\u003eWomen over 35 wanting a comprehensive hormonal and cardiometabolic health baseline\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr\u003e\n\u003ch2\u003eKey Features\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003e16-marker combined saliva LCMS hormone and cortisol panel plus blood spot cardiometabolic panel\u003c\/li\u003e\n\u003cli\u003eSaliva LCMS — the gold standard for bioavailable sex hormone measurement in women\u003c\/li\u003e\n\u003cli\u003eAll three oestrogens (E1, E2, E3) for complete oestrogen metabolism and dominance assessment\u003c\/li\u003e\n\u003cli\u003e4-point cortisol profile revealing the full daily adrenal rhythm and its metabolic consequences\u003c\/li\u003e\n\u003cli\u003eSix cardiometabolic markers — fasting insulin, HbA1c, HDL, triglycerides, total cholesterol, hsCRP\u003c\/li\u003e\n\u003cli\u003eResults within \u003cstrong\u003e3–5 working days\u003c\/strong\u003e after lab receipt\u003c\/li\u003e\n\u003cli\u003eExpert analysis by a \u003cstrong\u003eHormone Specialist PhD Doctor\u003c\/strong\u003e\n\u003c\/li\u003e\n\u003cli\u003eClear graphical and numerical results with personalised commentary\u003c\/li\u003e\n\u003cli\u003eAll-inclusive price — laboratory fees included, no hidden costs\u003c\/li\u003e\n\u003cli\u003eValid for 12 months from purchase\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr\u003e\n\u003ch2\u003eHow It Works\u003c\/h2\u003e\n\u003col\u003e\n\u003cli\u003e\n\u003cstrong\u003eOrder the kit online\u003c\/strong\u003e — delivered directly to your door.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCollect your saliva samples\u003c\/strong\u003e at four time points (morning, noon, evening, night) and your \u003cstrong\u003eblood spot sample\u003c\/strong\u003e via a simple finger-prick, following the detailed instructions provided. Guidance on optimal cycle timing is included.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePost your samples to the lab\u003c\/strong\u003e using the return instructions included in your kit.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eReceive your results within 3–5 working days\u003c\/strong\u003e, with specialist commentary and clear next-step guidance.\u003c\/li\u003e\n\u003c\/ol\u003e\n\u003chr\u003e\n\u003ch2\u003eWhat Your Report Includes\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003eAll 16 marker results with female-specific reference ranges\u003c\/li\u003e\n\u003cli\u003eVisual charts for all six sex hormones, your full 4-point cortisol daily curve, and all six cardiometabolic markers\u003c\/li\u003e\n\u003cli\u003eClinical interpretation of how your oestrogens, progesterone, cortisol, and cardiometabolic markers interact as an integrated female metabolic-hormonal system\u003c\/li\u003e\n\u003cli\u003eOestrogen-progesterone dominance ratio analysis\u003c\/li\u003e\n\u003cli\u003eInsulin resistance pattern assessment based on fasting insulin and HbA1c\u003c\/li\u003e\n\u003cli\u003eCardiovascular risk profile including HDL, triglycerides, and hsCRP in hormonal context\u003c\/li\u003e\n\u003cli\u003eSpecialist commentary by a Hormone Specialist PhD Doctor\u003c\/li\u003e\n\u003cli\u003ePersonalised next-step recommendations\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr\u003e\n\u003ch2\u003eFrequently Asked Questions\u003c\/h2\u003e\n\u003ch3\u003eWhat does this test measure?\u003c\/h3\u003e\n\u003cp\u003eOestradiol (E2), Oestriol (E3), Oestrone (E1), Progesterone, Testosterone, DHEAS (saliva LCMS) plus 4-point Cortisol (saliva: morning, noon, evening, night) plus Fasting Insulin, HbA1c, HDL Cholesterol, Triglycerides, Total Cholesterol, and hsCRP (blood spot) — 16 markers in total.\u003c\/p\u003e\n\u003ch3\u003eWhy should women test hormones and cardiometabolic markers together?\u003c\/h3\u003e\n\u003cp\u003eIn women, sex hormones and cardiometabolic health are mechanistically inseparable. Oestradiol protects HDL and suppresses cardiovascular inflammation; its decline after menopause directly raises cardiovascular risk. Cortisol drives insulin resistance and visceral fat; low progesterone worsens oestrogen dominance and inflammation. Testing both systems together reveals whether cardiometabolic symptoms are driven by hormonal root causes — something that testing either system alone cannot determine.\u003c\/p\u003e\n\u003ch3\u003eWhen in my cycle should I collect my samples?\u003c\/h3\u003e\n\u003cp\u003eGuidance on optimal cycle timing is included in the kit. For most women, collection in the luteal phase (days 19–21 of a 28-day cycle) provides the most clinically meaningful progesterone and oestrogen values alongside the metabolic markers.\u003c\/p\u003e\n\u003ch3\u003eCan I use this test if I am on HRT or the contraceptive pill?\u003c\/h3\u003e\n\u003cp\u003eYes. HRT and the contraceptive pill significantly affect oestrogen, progesterone, HDL, triglycerides, and insulin sensitivity — which is precisely why monitoring both hormonal and cardiometabolic markers together is more informative than standard blood tests for women on hormonal treatment. Follow the timing guidance in your kit.\u003c\/p\u003e\n\u003ch3\u003eIs this test suitable for women with PCOS?\u003c\/h3\u003e\n\u003cp\u003eYes — this test is particularly valuable for women with PCOS. PCOS is fundamentally a condition of insulin resistance, androgen excess, and oestrogen-progesterone imbalance — all of which are directly assessed by this panel. Fasting insulin is often the most clinically important marker in PCOS and is measured alongside the full sex hormone and cortisol profile.\u003c\/p\u003e\n\u003ch3\u003eWhen will I get my results?\u003c\/h3\u003e\n\u003cp\u003eWithin \u003cstrong\u003e3–5 working days\u003c\/strong\u003e after your samples reach the laboratory.\u003c\/p\u003e\n\u003ch3\u003eAre there hidden costs?\u003c\/h3\u003e\n\u003cp\u003eNo. Laboratory analysis and specialist review are fully included. You are responsible for postage to the lab.\u003c\/p\u003e\n\u003ch3\u003eHow long is the kit valid?\u003c\/h3\u003e\n\u003cp\u003e12 months from purchase.\u003c\/p\u003e\n\u003chr\u003e\n\u003ch2\u003eWhy We Partner with ZRT Laboratory\u003c\/h2\u003e\n\u003cp\u003eAt Hormone Lab UK, every home test kit is analysed by \u003cstrong\u003eZRT Laboratory\u003c\/strong\u003e, a globally recognised, \u003cstrong\u003eCLIA-certified\u003c\/strong\u003e diagnostic and research laboratory specialising in hormone testing, thyroid testing, fertility testing, adrenal function, neurotransmitter analysis, cardiometabolic health, heavy metals, and wellness testing. Founded in 1998 by renowned biochemist and breast cancer researcher \u003cstrong\u003eDr. David Zava, PhD\u003c\/strong\u003e, ZRT has become one of the world’s leading laboratories for advanced functional health testing.\u003c\/p\u003e\n\u003cp\u003eWith \u003cstrong\u003emore than 11 million laboratory tests\u003c\/strong\u003e performed and healthcare professionals in \u003cstrong\u003eover 96 countries\u003c\/strong\u003e relying on its expertise, ZRT is recognised for scientific excellence, analytical accuracy, and continuous innovation. The laboratory pioneered \u003cstrong\u003eat-home saliva hormone testing\u003c\/strong\u003e, introduced the \u003cstrong\u003efirst commercially available dried blood spot (DBS) hormone tests\u003c\/strong\u003e, and developed \u003cstrong\u003eDried Urine Testing (DUTS)\u003c\/strong\u003e, helping make advanced laboratory diagnostics more accessible and clinically meaningful.\u003c\/p\u003e\n\u003cp\u003eEvery sample is analysed using state-of-the-art \u003cstrong\u003eLC-MS\/MS\u003c\/strong\u003e and \u003cstrong\u003eICP-MS\u003c\/strong\u003e technology under rigorous quality control standards. ZRT collaborates with the \u003cstrong\u003eCDC\u003c\/strong\u003e, \u003cstrong\u003eNIH\u003c\/strong\u003e, and leading universities, supporting ongoing research and advances in laboratory medicine.\u003c\/p\u003e","brand":"Hormone Lab UK","offers":[{"title":"Default Title","offer_id":58618345816445,"sku":"SB-651-F","price":389.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1885\/4859\/files\/SalivaandBloodSpotHormoneTestKit.webp?v=1785073903","url":"https:\/\/hormonelab.co.uk\/fr\/products\/female-hormone-cardiometabolic-test","provider":"Hormone Lab UK","version":"1.0","type":"link"}