{"product_id":"male-comprehensive-hormone-profile-i","title":"Male Comprehensive Hormone + SHBG \u0026 Thyroid Profile | 18 Markers","description":"\u003cp\u003e\u003cstrong\u003eTest ID:\u003c\/strong\u003e SB-644 | \u003cstrong\u003eSample Type:\u003c\/strong\u003e Saliva + Dried Blood Spot | \u003cstrong\u003eTechnology:\u003c\/strong\u003e LC-MS\/MS | \u003cstrong\u003eResults Time:\u003c\/strong\u003e 3–5 Working Days After Laboratory Receives Sample | \u003cstrong\u003eLaboratory:\u003c\/strong\u003e ZRT Laboratory – CLIA Certified | \u003cstrong\u003eHormone Specialist Doctor Interpretation:\u003c\/strong\u003e Included | \u003cstrong\u003eSuitable For:\u003c\/strong\u003e Adults and Children | \u003cstrong\u003eCollect Sample At Home:\u003c\/strong\u003e No Clinic Visit Required\u003c\/p\u003e\n\u003ch2\u003eWhat Does This Test Measure?\u003c\/h2\u003e\n\u003cp\u003e\u003cstrong\u003eSaliva — 4-Point Cortisol Profile:\u003c\/strong\u003e Morning, Noon, Evening, and Night Cortisol.\u003cbr\u003e\u003cstrong\u003eBlood Spot — Sex Hormones + SHBG (LC-MS\/MS):\u003c\/strong\u003e Estradiol (E2), Estriol (E3), Estrone (E1), Progesterone, Testosterone, DHEAS, Cortisol, SHBG.\u003cbr\u003e\u003cstrong\u003eBlood Spot — Full Thyroid Panel:\u003c\/strong\u003e TSH, Free T3, Free T4, Total T4, TPO Antibodies, Thyroglobulin Antibodies.\u003cbr\u003e18 markers total — a complete picture of the daily cortisol rhythm, androgenic balance including SHBG, and autoimmune thyroid function in a single at-home kit.\u003c\/p\u003e\n\u003ch2\u003eRelated Symptoms\u003c\/h2\u003e\n\u003cp\u003ePersistent fatigue, unexplained weight gain, low libido, erectile dysfunction, poor exercise recovery, brain fog, low mood, feeling cold, dry skin, hair thinning, insomnia, chronic stress, burnout, symptoms of low testosterone with normal standard blood results, or told testosterone is “normal” but symptoms persist.\u003c\/p\u003e\n\u003ch2\u003eWho Should Consider This Test?\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003ePersistent fatigue that does not improve with rest or sleep\u003c\/li\u003e\n\u003cli\u003eUnexplained weight gain, particularly around the abdomen\u003c\/li\u003e\n\u003cli\u003eLow libido, erectile dysfunction, or reduced sexual performance\u003c\/li\u003e\n\u003cli\u003ePoor recovery from exercise or sustained high workload\u003c\/li\u003e\n\u003cli\u003eBrain fog, poor concentration, or low mood\u003c\/li\u003e\n\u003cli\u003eFeeling cold, dry skin, or hair thinning\u003c\/li\u003e\n\u003cli\u003eInsomnia, night waking, or unrefreshing sleep\u003c\/li\u003e\n\u003cli\u003eChronic stress or burnout\u003c\/li\u003e\n\u003cli\u003eTold testosterone is “normal” but symptoms of androgen deficiency persist (elevated SHBG is frequently the explanation)\u003c\/li\u003e\n\u003cli\u003eCurrently on TRT and wanting to monitor SHBG, thyroid, and estradiol alongside testosterone\u003c\/li\u003e\n\u003cli\u003eDiagnosed or suspected Hashimoto’s thyroiditis or autoimmune thyroid disease\u003c\/li\u003e\n\u003cli\u003eOn levothyroxine and wanting complete thyroid monitoring alongside SHBG and sex hormone levels\u003c\/li\u003e\n\u003cli\u003eMen who want the complete cortisol-SHBG-testosterone-thyroid picture without a cardiometabolic panel\u003c\/li\u003e\n\u003cli\u003eMen over 35 seeking a comprehensive androgenic, SHBG, cortisol rhythm, and thyroid health baseline\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch2\u003eWhy This Test Is Particularly Important for Men\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003eThe 4-point cortisol rhythm is the master regulator of SHBG, free testosterone, and thyroid T3 activation — each time point has distinct androgenic and thyroid consequences that a single cortisol measurement cannot identify\u003c\/li\u003e\n\u003cli\u003eSHBG is the most commonly missed cause of low testosterone symptoms in men with “normal” blood results — elevated by cortisol, thyroid disease, estradiol excess, age, and caloric restriction\u003c\/li\u003e\n\u003cli\u003eThyroid dysfunction suppresses Leydig cell testosterone production and elevates SHBG — cortisol-driven T3 suppression produces identical symptoms with a normal TSH; Hashimoto’s is present years before TSH becomes abnormal\u003c\/li\u003e\n\u003cli\u003eNight cortisol elevation suppresses overnight testosterone production and worsens Hashimoto’s autoimmune activity simultaneously — detectable only by the 4-point cortisol assessment\u003c\/li\u003e\n\u003cli\u003eBoth TPO and Tg antibodies are required for complete Hashimoto’s screening — some men have elevated Tg antibodies with normal TPO\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch2\u003eHow This Profile Differs From Other Tests\u003c\/h2\u003e\n\u003cp\u003eThe Male Comprehensive Hormone + SHBG \u0026amp; Thyroid Profile \u003cstrong\u003e(SB-644)\u003c\/strong\u003e provides the 4-point cortisol rhythm, full LC-MS\/MS sex hormones + SHBG, and full thyroid panel — without the cardiometabolic panel. It is the ideal choice for men who want the complete cortisol-SHBG-testosterone-thyroid assessment, or who are adding targeted metabolic testing separately. For the cardiometabolic panel alongside this assessment, see the \u003cstrong\u003eMale Comprehensive Hormone, Thyroid \u0026amp; CardioMetabolic Profile (SB-646M)\u003c\/strong\u003e.\u003c\/p\u003e\n\u003ch2\u003eNot Sure Which Test Is Right for You?\u003c\/h2\u003e\n\u003cp\u003eEmail us at \u003ca href=\"mailto:info@hormonelab.co.uk\"\u003einfo@hormonelab.co.uk\u003c\/a\u003e with your gender, age, symptoms, medications, and any current treatments. We will forward your enquiry to our doctors and respond within 24 hours.\u003c\/p\u003e\n\u003ch2\u003eHow It Works\u003c\/h2\u003e\n\u003col\u003e\n\u003cli\u003eOrder your kit — delivered directly to your door\u003c\/li\u003e\n\u003cli\u003eCollect saliva at four time points (morning before 9am, noon, evening, night) and blood spot via finger-prick\u003c\/li\u003e\n\u003cli\u003ePost your samples to ZRT Laboratory using the return instructions provided\u003c\/li\u003e\n\u003cli\u003eReceive your full report by email within 3–5 working days\u003c\/li\u003e\n\u003c\/ol\u003e\n\u003ch2\u003eWhat You Receive\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli\u003eAll 18 marker results with male-specific reference ranges\u003c\/li\u003e\n\u003cli\u003eVisual cortisol rhythm chart showing your full four-point daily curve\u003c\/li\u003e\n\u003cli\u003eVisual charts for all sex hormones, SHBG, and the full thyroid panel\u003c\/li\u003e\n\u003cli\u003eIntegrated clinical interpretation of how cortisol rhythm, testosterone, SHBG, estradiol, and thyroid markers interact as a single male hormonal system by a Hormone Specialist PhD Doctor\u003c\/li\u003e\n\u003cli\u003eSHBG-adjusted free testosterone bioavailability assessment\u003c\/li\u003e\n\u003cli\u003eCortisol-thyroid T3 and Hashimoto’s autoimmunity assessment in cortisol and SHBG context\u003c\/li\u003e\n\u003cli\u003ePersonalised next-step recommendations\u003c\/li\u003e\n\u003cli\u003eLaboratory fee included — no hidden charges\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch2\u003eWhy We Use ZRT Laboratory\u003c\/h2\u003e\n\u003cp\u003eAll testing is performed by \u003cstrong\u003eZRT Laboratory\u003c\/strong\u003e — a globally recognised, \u003cstrong\u003eCLIA-certified\u003c\/strong\u003e diagnostic laboratory founded in 1998 by \u003cstrong\u003eDr. David Zava, PhD\u003c\/strong\u003e. ZRT has performed \u003cstrong\u003eover 11 million tests\u003c\/strong\u003e and is trusted by healthcare professionals in \u003cstrong\u003e96+ countries\u003c\/strong\u003e.\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003ePioneers of at-home \u003cstrong\u003edried blood spot (DBS)\u003c\/strong\u003e and saliva hormone testing\u003c\/li\u003e\n\u003cli\u003eAdvanced \u003cstrong\u003eLC-MS\/MS\u003c\/strong\u003e technology for clinical-grade accuracy\u003c\/li\u003e\n\u003cli\u003eQualified for the \u003cstrong\u003eCDC Hormone Standardization (HoSt) Program\u003c\/strong\u003e\n\u003c\/li\u003e\n\u003cli\u003ePersonalised reference ranges based on age and sex\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eThrough our partnership with ZRT Laboratory, Hormone Lab UK delivers internationally recognised, research-backed hormone testing to people across the UK and Europe — from the comfort of home.\u003c\/p\u003e\n\u003ch2\u003eFrequently Asked Questions\u003c\/h2\u003e\n\u003cp\u003e\u003cstrong\u003eDoes this test include cardiometabolic markers?\u003c\/strong\u003e\u003cbr\u003eNo. This profile covers the cortisol rhythm, sex hormones, SHBG, and full thyroid panel. For fasting insulin, HbA1c, HDL, triglycerides, cholesterol, and hsCRP alongside this panel, see the \u003cstrong\u003eMale Comprehensive Hormone, Thyroid \u0026amp; CardioMetabolic Profile (SB-646M)\u003c\/strong\u003e.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eWhy is TSH alone not enough?\u003c\/strong\u003e\u003cbr\u003eTSH measures the pituitary signal to the thyroid, not the active T3 reaching cells. Cortisol-driven T3 suppression produces functional hypothyroidism and Leydig cell testosterone suppression with a normal TSH. Hashimoto’s causes progressive thyroid damage for years before TSH becomes abnormal. SHBG elevation from thyroid disease further inactivates testosterone. All three patterns are invisible to TSH alone.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eWhy do I need SHBG alongside testosterone?\u003c\/strong\u003e\u003cbr\u003eSHBG binds and inactivates testosterone. A man with elevated SHBG — from cortisol, thyroid disease, or estradiol excess — has full androgenic deficiency symptoms despite a normal total testosterone. This panel identifies both the SHBG level and, through the 4-point cortisol rhythm and thyroid panel, the most likely mechanism driving it.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eCan I use this test if I am on TRT or levothyroxine?\u003c\/strong\u003e\u003cbr\u003eYes. This test monitors SHBG, estradiol, thyroid function, and cortisol rhythm alongside testosterone — essential for safe TRT management and accurate levothyroxine dosing.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eDoes the price include the laboratory fee?\u003c\/strong\u003e\u003cbr\u003eYes. The full laboratory analysis fee is included. There are no additional charges. You are only responsible for posting your samples to the laboratory.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eHow long is the kit valid for?\u003c\/strong\u003e\u003cbr\u003eThe kit must be used within \u003cstrong\u003e12 months\u003c\/strong\u003e of the purchase date.\u003c\/p\u003e","brand":"Hormone Lab UK","offers":[{"title":"Default Title","offer_id":57961680306557,"sku":"1021","price":399.0,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1885\/4859\/files\/Male-Comprehensive-Hormone-SHBG-and-Thyroid-Profile.webp?v=1792877439","url":"https:\/\/hormonelab.co.uk\/de\/products\/male-comprehensive-hormone-profile-i","provider":"Hormone Lab UK","version":"1.0","type":"link"}